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  • 1
    Publication Date: 2016-07-26
    Description: Although the time-averaged shear-wave velocity down to 30 m depth ( V S 30 ) can be a proxy for estimating earthquake ground-motion amplification, significant controversy exists about its limitations when used as a single parameter for the prediction of amplification. To examine this question in absence of relevant strong-motion records, we use a range of different methods to measure the shear-wave velocity profiles and the resulting theoretical site amplification factors (AFs) for 30 sites in the Newcastle area, Australia, in a series of blind comparison studies. The multimethod approach used here combines past seismic cone penetrometer and spectral analysis of surface-wave data, with newly acquired horizontal-to-vertical spectral ratio, passive-source surface-wave spatial autocorrelation (SPAC), refraction microtremor (ReMi), and multichannel analysis of surface-wave data. The various measurement techniques predicted a range of different AFs. The SPAC and ReMi techniques have the smallest overall deviation from the median AF for the majority of sites. We show that V S 30 can be related to spectral response above a period T of 0.5 s but not necessarily with the maximum amplification according to the modeling done based on the measured shear-wave velocity profiles. Both V S 30 and AF values are influenced by the velocity ratio between bedrock and overlying sediments and the presence of surficial thin low-velocity layers (〈2 m thick and 〈150 m/s), but the velocity ratio is what mostly affects the AF. At 0.2〈 T 〈0.4 s, the AFs are largely controlled by the surficial geology of a particular site. AF maxima are the highest in the hard classes, which is the inverse of the findings used in the Australian Building Code. Only for T 〉0.5 s do the amplification curves consistently show higher values for soft site classes and lower for hard classes.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 2
    Publication Date: 2016-07-26
    Description: In 2001, a rare swarm of small, shallow earthquakes beneath the city of Spokane, Washington, caused ground shaking as well as audible booms over a five-month period. Subsequent Interferometric Synthetic Aperture Radar (InSAR) data analysis revealed an area of surface uplift in the vicinity of the earthquake swarm. To investigate the potential faults that may have caused both the earthquakes and the topographic uplift, we collected ~3 km of high-resolution seismic-reflection profiles to image the upper-source region of the swarm. The two profiles reveal a complex deformational pattern within Quaternary alluvial, fluvial, and flood deposits, underlain by Tertiary basalts and basin sediments. At least 100 m of arching on a basalt surface in the upper 500 m is interpreted from both the seismic profiles and magnetic modeling. Two west-dipping faults deform Quaternary sediments and project to the surface near the location of the Spokane fault defined from modeling of the InSAR data.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 3
    Publication Date: 2013-10-01
    Description: Shear-wave velocity ( V S ) and time-averaged shear-wave velocity to 30 m depth ( V S 30 ) are the key parameters used in seismic site response modeling and earthquake engineering design. Where V S data are limited, available data are often used to develop and refine map-based proxy models of V S 30 for predicting ground-motion intensities. In this paper, we present shallow V S data from 27 sites in Puerto Rico. These data were acquired using a multimethod acquisition approach consisting of noninvasive, collocated, active-source body-wave (refraction/reflection), active-source surface wave at nine sites, and passive-source surface-wave refraction microtremor (ReMi) techniques. V S -versus-depth models are constructed and used to calculate spectral response plots for each site. Factors affecting method reliability are analyzed with respect to site-specific differences in bedrock V S and spectral response. At many but not all sites, body- and surface-wave methods generally determine similar depths to bedrock, and it is the difference in bedrock V S that influences site amplification. The predicted resonant frequencies for the majority of the sites are observed to be within a relatively narrow bandwidth of 1–3.5 Hz. For a first-order comparison of peak frequency position, predictive spectral response plots from eight sites are plotted along with seismograph instrument spectra derived from the time series of the 16 May 2010 Puerto Rico earthquake. We show how a multimethod acquisition approach using collocated arrays compliments and corroborates V S results, thus adding confidence that reliable site characterization information has been obtained.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 4
    Publication Date: 2013-10-01
    Description: We characterize shallow subsurface faulting and basin structure along a transect through heavily urbanized Reno, Nevada, with high-resolution seismic reflection imaging. The 6.8 km of P -wave data image the subsurface to approximately 800 m depth and delineate two subbasins and basin uplift that are consistent with structure previously inferred from gravity modeling in this region of the northern Walker Lane. We interpret two primary faults that bound the uplift and deform Quaternary deposits. The dip of Quaternary and Tertiary strata in the western subbasin increases with greater depth to the east, suggesting recurrent fault motion across the westernmost of these faults. Deformation in the Quaternary section of the western subbasin is likely evidence of extensional growth folding at the edge of the Truckee River through Reno. This deformation is north of, and on trend with, previously mapped Quaternary fault strands of the Mt. Rose fault zone. In addition to corroborating the existence of previously inferred intrabasin structure, these data provide evidence for an active extensional Quaternary fault at a previously unknown location within the Truckee Meadows basin that furthers our understanding of both the seismotectonic framework and earthquake hazards in this urbanized region.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 5
    Publication Date: 2018
    Description: 〈p〉We estimated the genome-wide contribution of recessive coding variation in 6040 families from the Deciphering Developmental Disorders study. The proportion of cases attributable to recessive coding variants was 3.6% in patients of European ancestry, compared with 50% explained by de novo coding mutations. It was higher (31%) in patients with Pakistani ancestry, owing to elevated autozygosity. Half of this recessive burden is attributable to known genes. We identified two genes not previously associated with recessive developmental disorders, 〈i〉KDM5B〈/i〉 and 〈i〉EIF3F〈/i〉, and functionally validated them with mouse and cellular models. Our results suggest that recessive coding variants account for a small fraction of currently undiagnosed nonconsanguineous individuals, and that the role of noncoding variants, incomplete penetrance, and polygenic mechanisms need further exploration.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2019
    Description: 〈p〉 A nearly 20-year hiatus in major seismic activity in southern California ended on 4 July 2019 with a sequence of intersecting earthquakes near the city of Ridgecrest, California. This sequence included a foreshock with a moment magnitude (〈i〉M〈/i〉〈sub〉w〈/sub〉) of 6.4 followed by a 〈i〉M〈/i〉〈sub〉w〈/sub〉 7.1 mainshock nearly 34 hours later. Geodetic, seismic, and seismicity data provided an integrative view of this sequence, which ruptured an unmapped multiscale network of interlaced orthogonal faults. This complex fault geometry persists over the entire seismogenic depth range. The rupture of the mainshock terminated only a few kilometers from the major regional Garlock fault, triggering shallow creep and a substantial earthquake swarm. The repeated occurrence of multifault ruptures, as revealed by modern instrumentation and analysis techniques, poses a formidable challenge in quantifying regional seismic hazards.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2019
    Description: 〈span〉〈div〉ABSTRACT〈/div〉Characterizing earthquake ground motions through 3D simulations is becoming standard practice for seismic hazard assessment in urbanized regions. However, accurate ground‐motion predictions require shear‐wave velocity (VS) data at depths that capture the extent of the sedimentary column (usually greater than 30 m), which can be difficult to obtain. We acquired microtremor array data at 11 sites in the Seattle basin, Washington, and applied the wavenumber‐normalized spatial autocorrelation (SPAC) method (krSPAC) to obtain VS at depths as great as 2200 m. In a traditional SPAC approach, modeling high wavenumbers within the SPAC spectrum requires array symmetry. By contrast, in the krSPAC approach we transform observed coherency versus frequency spectra to coherency versus kr (in which k and r are wavenumber and station separation, respectively) prior to VS modeling. Through this transformation, the requirement for array symmetry is eased. We deployed seven‐sensor nested irregular triangular arrays, with nominal interstation spacings that varied from about 300 to 2000 m. Comparison of VS derived from krSPAC to a previous interpretation from ambient‐noise tomography studies suggests a broadly comparable VS structure in the 250–1000 m depth range with improved resolution at shallower depth. At each site, we interpret a high‐velocity Quaternary boundary in which VS increases above 900  m/s. Using this boundary as the reference horizon, we calculate ground‐motion amplification of a factor of up to 2 from the overlying Quaternary sediments between 0.3 and 7 Hz, assuming vertically propagating 〈span〉S〈/span〉 waves.〈/span〉
    Print ISSN: 0895-0695
    Electronic ISSN: 1938-2057
    Topics: Geosciences
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  • 8
    Publication Date: 2019
    Description: 〈p〉To date, sea slugs have been considered the only animals known to sequester functional algal plastids into their own cells, via a process called "kleptoplasty." We report here, however, that endosymbionts in the marine flatworms 〈i〉Baicalellia solaris〈/i〉 and 〈i〉Pogaina paranygulgus〈/i〉 are isolated plastids stolen from diatoms. Ultrastructural data show that kleptoplasts are located within flatworm cells, while algal nuclei and other organelles are absent. Transcriptomic analysis and 〈i〉rbcL〈/i〉 amplicons confirm the absence of algal nuclear mRNA and reveal that the plastids originate from different species of diatoms. Laboratory experiments demonstrated photosynthetic activity and short-term retention of kleptoplasts in starved worms. This lineage of flatworms represents the first known case of functional kleptoplasty involving diatoms and only the second known case of kleptoplasty across the entire tree of animals.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 9
    Publication Date: 2012-04-01
    Description: We conducted active and passive seismic imaging investigations along a 5.6-km-long, east–west transect ending at the mapped trace of the Wasatch fault in southern Utah Valley. Using two-dimensional (2D) P-wave seismic reflection data, we imaged basin deformation and faulting to a depth of 1.4 km and developed a detailed interval velocity model for prestack depth migration and 2D ground-motion simulations. Passive-source microtremor data acquired at two sites along the seismic reflection transect resolve S-wave velocities of approximately 200??m/s at the surface to about 900??m/s at 160 m depth and confirm a substantial thickening of low-velocity material westward into the valley. From the P-wave reflection profile, we interpret shallow (100–600 m) bedrock deformation extending from the surface trace of the Wasatch fault to roughly 1.5 km west into the valley. The bedrock deformation is caused by multiple interpreted fault splays displacing fault blocks downward to the west of the range front. Further west in the valley, the P-wave data reveal subhorizontal horizons from approximately 90 to 900 m depth that vary in thickness and whose dip increases with depth eastward toward the Wasatch fault. Another inferred fault about 4 km west of the mapped Wasatch fault displaces horizons within the valley to as shallow as 100 m depth. The overall deformational pattern imaged in our data is consistent with the Wasatch fault migrating eastward through time and with the abandonment of earlier synextensional faults, as part of the evolution of an inferred 20-km-wide half-graben structure within Utah Valley. Finite-difference 2D modeling suggests the imaged subsurface basin geometry can cause fourfold variation in peak ground velocity over distances of 300 m.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 10
    Publication Date: 2002-06-01
    Description: The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mural, Richard J -- Adams, Mark D -- Myers, Eugene W -- Smith, Hamilton O -- Miklos, George L Gabor -- Wides, Ron -- Halpern, Aaron -- Li, Peter W -- Sutton, Granger G -- Nadeau, Joe -- Salzberg, Steven L -- Holt, Robert A -- Kodira, Chinnappa D -- Lu, Fu -- Chen, Lin -- Deng, Zuoming -- Evangelista, Carlos C -- Gan, Weiniu -- Heiman, Thomas J -- Li, Jiayin -- Li, Zhenya -- Merkulov, Gennady V -- Milshina, Natalia V -- Naik, Ashwinikumar K -- Qi, Rong -- Shue, Bixiong Chris -- Wang, Aihui -- Wang, Jian -- Wang, Xin -- Yan, Xianghe -- Ye, Jane -- Yooseph, Shibu -- Zhao, Qi -- Zheng, Liansheng -- Zhu, Shiaoping C -- Biddick, Kendra -- Bolanos, Randall -- Delcher, Arthur L -- Dew, Ian M -- Fasulo, Daniel -- Flanigan, Michael J -- Huson, Daniel H -- Kravitz, Saul A -- Miller, Jason R -- Mobarry, Clark M -- Reinert, Knut -- Remington, Karin A -- Zhang, Qing -- Zheng, Xiangqun H -- Nusskern, Deborah R -- Lai, Zhongwu -- Lei, Yiding -- Zhong, Wenyan -- Yao, Alison -- Guan, Ping -- Ji, Rui-Ru -- Gu, Zhiping -- Wang, Zhen-Yuan -- Zhong, Fei -- Xiao, Chunlin -- Chiang, Chia-Chien -- Yandell, Mark -- Wortman, Jennifer R -- Amanatides, Peter G -- Hladun, Suzanne L -- Pratts, Eric C -- Johnson, Jeffery E -- Dodson, Kristina L -- Woodford, Kerry J -- Evans, Cheryl A -- Gropman, Barry -- Rusch, Douglas B -- Venter, Eli -- Wang, Mei -- Smith, Thomas J -- Houck, Jarrett T -- Tompkins, Donald E -- Haynes, Charles -- Jacob, Debbie -- Chin, Soo H -- Allen, David R -- Dahlke, Carl E -- Sanders, Robert -- Li, Kelvin -- Liu, Xiangjun -- Levitsky, Alexander A -- Majoros, William H -- Chen, Quan -- Xia, Ashley C -- Lopez, John R -- Donnelly, Michael T -- Newman, Matthew H -- Glodek, Anna -- Kraft, Cheryl L -- Nodell, Marc -- Ali, Feroze -- An, Hui-Jin -- Baldwin-Pitts, Danita -- Beeson, Karen Y -- Cai, Shuang -- Carnes, Mark -- Carver, Amy -- Caulk, Parris M -- Center, Angela -- Chen, Yen-Hui -- Cheng, Ming-Lai -- Coyne, My D -- Crowder, Michelle -- Danaher, Steven -- Davenport, Lionel B -- Desilets, Raymond -- Dietz, Susanne M -- Doup, Lisa -- Dullaghan, Patrick -- Ferriera, Steven -- Fosler, Carl R -- Gire, Harold C -- Gluecksmann, Andres -- Gocayne, Jeannine D -- Gray, Jonathan -- Hart, Brit -- Haynes, Jason -- Hoover, Jeffery -- Howland, Tim -- Ibegwam, Chinyere -- Jalali, Mena -- Johns, David -- Kline, Leslie -- Ma, Daniel S -- MacCawley, Steven -- Magoon, Anand -- Mann, Felecia -- May, David -- McIntosh, Tina C -- Mehta, Somil -- Moy, Linda -- Moy, Mee C -- Murphy, Brian J -- Murphy, Sean D -- Nelson, Keith A -- Nuri, Zubeda -- Parker, Kimberly A -- Prudhomme, Alexandre C -- Puri, Vinita N -- Qureshi, Hina -- Raley, John C -- Reardon, Matthew S -- Regier, Megan A -- Rogers, Yu-Hui C -- Romblad, Deanna L -- Schutz, Jakob -- Scott, John L -- Scott, Richard -- Sitter, Cynthia D -- Smallwood, Michella -- Sprague, Arlan C -- Stewart, Erin -- Strong, Renee V -- Suh, Ellen -- Sylvester, Karena -- Thomas, Reginald -- Tint, Ni Ni -- Tsonis, Christopher -- Wang, Gary -- Wang, George -- Williams, Monica S -- Williams, Sherita M -- Windsor, Sandra M -- Wolfe, Keriellen -- Wu, Mitchell M -- Zaveri, Jayshree -- Chaturvedi, Kabir -- Gabrielian, Andrei E -- Ke, Zhaoxi -- Sun, Jingtao -- Subramanian, Gangadharan -- Venter, J Craig -- Pfannkoch, Cynthia M -- Barnstead, Mary -- Stephenson, Lisa D -- New York, N.Y. -- Science. 2002 May 31;296(5573):1661-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA. richard.mural@celera.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12040188" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Composition ; Chromosomes/*genetics ; Chromosomes, Human/genetics ; Computational Biology ; Conserved Sequence ; Databases, Nucleic Acid ; Evolution, Molecular ; Genes ; Genetic Markers ; *Genome ; *Genome, Human ; Genomics ; Humans ; Mice ; Mice, Inbred A/genetics ; Mice, Inbred DBA/genetics ; Mice, Inbred Strains/*genetics ; Molecular Sequence Data ; Physical Chromosome Mapping ; Proteins/chemistry/genetics ; Sequence Alignment ; *Sequence Analysis, DNA ; Species Specificity ; *Synteny
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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