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  • Oxford University Press  (55)
  • American Association for the Advancement of Science (AAAS)  (17)
  • 1
    Publikationsdatum: 2011-11-24
    Beschreibung: With the advent of molecular phylogenetics, the systematics and taxonomy of Patellogastropoda have been greatly improved. Eight families and 36 genera are currently recognized in the order. We review recent published papers that have used molecular data, discuss the resulting advances in systematics and evolution of Patellogastropoda and suggest directions of future research.
    Print ISSN: 0260-1230
    Digitale ISSN: 1464-3766
    Thema: Biologie
    Publiziert von Oxford University Press
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Publikationsdatum: 2018-03-30
    Beschreibung: The specific effects of sleep on synaptic plasticity remain unclear. We report that mouse hippocampal sharp-wave ripple oscillations serve as intrinsic events that trigger long-lasting synaptic depression. Silencing of sharp-wave ripples during slow-wave states prevented the spontaneous down-regulation of net synaptic weights and impaired the learning of new memories. The synaptic down-regulation was dependent on the N -methyl- d -aspartate receptor and selective for a specific input pathway. Thus, our findings are consistent with the role of slow-wave states in refining memory engrams by reducing recent memory-irrelevant neuronal activity and suggest a previously unrecognized function for sharp-wave ripples.
    Schlagwort(e): Neuroscience
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2012-04-16
    Beschreibung: This study was designed to elucidate details of the structure and formation process of the alternate lamellar pattern known to exist in lamellar bone. For this purpose, we examined basic internal lamellae in femurs of young rats by transmission and scanning electron microscopy, the latter employing two different macerations with NaOH at concentrations of 10 and 24%. Observations after the maceration with 10% NaOH showed that the regular and periodic rotation of collagen fibrils caused an alternation between two types of lamellae: one consisting of transversely and nearly transversely cut fibrils, and the other consisting of longitudinally and nearly longitudinally cut fibrils. This finding confirms the consistency of the twisted plywood model. The maceration method with 24% NaOH removed bone components other than cells, thus allowing for three-dimensional observations of osteoblast morphology. Osteoblasts extended finger-like processes paralleling the inner bone surface, and grouped in such a way that, within a group, the processes arranged in a similar direction. Transmission electron microscopy showed that newly deposited fibrils were arranged alongside these processes. For the formation of the alternating pattern, our findings suggest that: (1) osteoblasts control the collagen fibril arrangement through their finger-like process position; (2) osteoblasts behave similarly within a group; (3) osteoblasts move their processes synchronously and periodically to promote alternating different fibril orientation; and (4) this dynamic sequential deposition of fibrils results in the alternate lamellar (or twisted plywood) pattern.
    Print ISSN: 0022-0744
    Digitale ISSN: 1477-9986
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Publikationsdatum: 2000-02-11
    Beschreibung: Phosphoinositide 3-kinases (PI3Ks) regulate fundamental cellular responses such as proliferation, apoptosis, cell motility, and adhesion. Viable gene-targeted mice lacking the p110 catalytic subunit of PI3Kgamma were generated. We show that PI3Kgamma controls thymocyte survival and activation of mature T cells but has no role in the development or function of B cells. PI3Kgamma-deficient neutrophils exhibited severe defects in migration and respiratory burst in response to heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPCR) agonists and chemotactic agents. PI3Kgamma links GPCR stimulation to the formation of phosphatidylinositol 3,4,5-triphosphate and the activation of protein kinase B, ribosomal protein S6 kinase, and extracellular signal-regulated kinases 1 and 2. Thus, PI3Kgamma regulates thymocyte development, T cell activation, neutrophil migration, and the oxidative burst.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sasaki, T -- Irie-Sasaki, J -- Jones, R G -- Oliveira-dos-Santos, A J -- Stanford, W L -- Bolon, B -- Wakeham, A -- Itie, A -- Bouchard, D -- Kozieradzki, I -- Joza, N -- Mak, T W -- Ohashi, P S -- Suzuki, A -- Penninger, J M -- New York, N.Y. -- Science. 2000 Feb 11;287(5455):1040-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Amgen Institute, 620 University Avenue, Toronto M5G 2C1, Ontario, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10669416" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, CD/analysis ; Apoptosis ; Cell Line ; Chemotactic Factors/pharmacology ; Chemotaxis, Leukocyte/*physiology ; Heterotrimeric GTP-Binding Proteins/metabolism ; Lymph Nodes/cytology ; *Lymphocyte Activation ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinases/metabolism ; Neutrophils/*physiology ; Peritonitis/immunology ; Phosphatidylinositol 3-Kinases/*metabolism ; Phosphatidylinositol Phosphates/metabolism ; *Protein-Serine-Threonine Kinases ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-akt ; Respiratory Burst ; Signal Transduction ; Spleen/cytology ; T-Lymphocytes/cytology/*immunology ; Thymus Gland/*cytology/immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2002-04-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leach, Jan -- McCouch, Susan -- Slezak, Tom -- Sasaki, Takuji -- Wessler, Sue -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):45.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11962488" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Crops, Agricultural/genetics ; Edible Grain/genetics ; Genes, Plant ; *Genome, Plant ; International Cooperation ; Oryza/*genetics ; Private Sector ; Public Sector ; *Sequence Analysis, DNA ; Synteny
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Publikationsdatum: 1989-01-13
    Beschreibung: The chemical synthesis of biologically active peptides and polypeptides can be achieved by using a convergent strategy of condensing protected peptide segments to form the desired molecule. An oxime support increases the ease with which intermediate protected peptides can be synthesized and makes this approach useful for the synthesis of peptides in which secondary structural elements have been redesigned. The extension of these methods to large peptides and proteins, for which folding of secondary structures into functional tertiary structures is critical, is discussed. Models of apolipoproteins, the homeo domain from the developmental protein encoded by the Antennapedia gene of Drosophila, a part of the Cro repressor, and the enzyme ribonuclease T1 and a structural analog have been synthesized with this method.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Mihara, H -- Laforet, G A -- Kelly, J W -- Walters, L -- Findeis, M A -- Sasaki, T -- DK07825/DK/NIDDK NIH HHS/ -- GM12054/GM/NIGMS NIH HHS/ -- HL-186577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1989 Jan 13;243(4888):187-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Bioorganic Chemistry and Biochemistry, Rockefeller University, New York, NY 10021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2492114" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins A/chemical synthesis ; Humans ; Indicators and Reagents ; Lipoproteins, HDL/chemical synthesis ; Peptides/*chemical synthesis ; Protein Conformation ; Proteins/*chemical synthesis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Publikationsdatum: 2006-10-21
    Beschreibung: The intensity of Galactic cosmic rays is nearly isotropic because of the influence of magnetic fields in the Milky Way. Here, we present two-dimensional high-precision anisotropy measurement for energies from a few to several hundred teraelectronvolts (TeV), using the large data sample of the Tibet Air Shower Arrays. Besides revealing finer details of the known anisotropies, a new component of Galactic cosmic ray anisotropy in sidereal time is uncovered around the Cygnus region direction. For cosmic-ray energies up to a few hundred TeV, all components of anisotropies fade away, showing a corotation of Galactic cosmic rays with the local Galactic magnetic environment. These results have broad implications for a comprehensive understanding of cosmic rays, supernovae, magnetic fields, and heliospheric and Galactic dynamic environments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amenomori, M -- Ayabe, S -- Bi, X J -- Chen, D -- Cui, S W -- Danzengluobu -- Ding, L K -- Ding, X H -- Feng, C F -- Feng, Zhaoyang -- Feng, Z Y -- Gao, X Y -- Geng, Q X -- Guo, H W -- He, H H -- He, M -- Hibino, K -- Hotta, N -- Hu, Haibing -- Hu, H B -- Huang, J -- Huang, Q -- Jia, H Y -- Kajino, F -- Kasahara, K -- Katayose, Y -- Kato, C -- Kawata, K -- Labaciren -- Le, G M -- Li, A F -- Li, J Y -- Lou, Y-Q -- Lu, H -- Lu, S L -- Meng, X R -- Mizutani, K -- Mu, J -- Munakata, K -- Nagai, A -- Nanjo, H -- Nishizawa, M -- Ohnishi, M -- Ohta, I -- Onuma, H -- Ouchi, T -- Ozawa, S -- Ren, J R -- Saito, T -- Saito, T Y -- Sakata, M -- Sako, T K -- Sasaki, T -- Shibata, M -- Shiomi, A -- Shirai, T -- Sugimoto, H -- Takita, M -- Tan, Y H -- Tateyama, N -- Torii, S -- Tsuchiya, H -- Udo, S -- Wang, B -- Wang, H -- Wang, X -- Wang, Y G -- Wu, H R -- Xue, L -- Yamamoto, Y -- Yan, C T -- Yang, X C -- Yasue, S -- Ye, Z H -- Yu, G C -- Yuan, A F -- Yuda, T -- Zhang, H M -- Zhang, J L -- Zhang, N J -- Zhang, X Y -- Zhang, Y -- Zhang, Yi -- Zhaxisangzhu -- Zhou, X X -- Tibet ASgamma Collaboration -- New York, N.Y. -- Science. 2006 Oct 20;314(5798):439-43.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Hirosaki University, Hirosaki 036-8561, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17053141" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 8
    Publikationsdatum: 2008-02-02
    Beschreibung: Core-collapse supernovae (CC-SNe) are the explosions that announce the death of massive stars. Some CC-SNe are linked to long-duration gamma-ray bursts (GRBs) and are highly aspherical. One important question is to what extent asphericity is common to all CC-SNe. Here we present late-time spectra for a number of CC-SNe from stripped-envelope stars and use them to explore any asphericity generated in the inner part of the exploding star, near the site of collapse. A range of oxygen emission-line profiles is observed, including a high incidence of double-peaked profiles, a distinct signature of an aspherical explosion. Our results suggest that all CC-SNe from stripped-envelope stars are aspherical explosions and that SNe accompanied by GRBs exhibit the highest degree of asphericity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maeda, Keiichi -- Kawabata, Koji -- Mazzali, Paolo A -- Tanaka, Masaomi -- Valenti, Stefano -- Nomoto, Ken'ichi -- Hattori, Takashi -- Deng, Jinsong -- Pian, Elena -- Taubenberger, Stefan -- Iye, Masanori -- Matheson, Thomas -- Filippenko, Alexei V -- Aoki, Kentaro -- Kosugi, George -- Ohyama, Youichi -- Sasaki, Toshiyuki -- Takata, Tadafumi -- New York, N.Y. -- Science. 2008 Feb 29;319(5867):1220-3. doi: 10.1126/science.1149437. Epub 2008 Jan 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for the Physics and Mathematics of the Universe (IPMU), University of Tokyo, Kashiwa-no-ha 5-1-5, Kashiwa City, Chiba 277-8582, Japan. maeda@ea.c.u-tokyo.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18239091" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2011-02-05
    Beschreibung: Once initiated near the soma, an action potential (AP) is thought to propagate autoregeneratively and distribute uniformly over axonal arbors. We challenge this classic view by showing that APs are subject to waveform modulation while they travel down axons. Using fluorescent patch-clamp pipettes, we recorded APs from axon branches of hippocampal CA3 pyramidal neurons ex vivo. The waveforms of axonal APs increased in width in response to the local application of glutamate and an adenosine A(1) receptor antagonist to the axon shafts, but not to other unrelated axon branches. Uncaging of calcium in periaxonal astrocytes caused AP broadening through ionotropic glutamate receptor activation. The broadened APs triggered larger calcium elevations in presynaptic boutons and facilitated synaptic transmission to postsynaptic neurons. This local AP modification may enable axonal computation through the geometry of axon wiring.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sasaki, Takuya -- Matsuki, Norio -- Ikegaya, Yuji -- New York, N.Y. -- Science. 2011 Feb 4;331(6017):599-601. doi: 10.1126/science.1197598.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21292979" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Action Potentials/drug effects ; Adenosine/metabolism/pharmacology ; Adenosine A1 Receptor Antagonists/pharmacology ; Animals ; Astrocytes/metabolism ; Axons/drug effects/*physiology ; CA3 Region, Hippocampal/*cytology/physiology ; Calcium/metabolism ; Excitatory Postsynaptic Potentials ; Glutamic Acid/pharmacology ; In Vitro Techniques ; Patch-Clamp Techniques ; Potassium Channels/metabolism ; Presynaptic Terminals/physiology ; Pyramidal Cells/*physiology ; Rats ; Rats, Wistar ; Receptor, Adenosine A1/metabolism ; Receptors, AMPA/metabolism ; *Synaptic Transmission ; Xanthines/pharmacology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Publikationsdatum: 1997-10-10
    Beschreibung: Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boshoff, C -- Endo, Y -- Collins, P D -- Takeuchi, Y -- Reeves, J D -- Schweickart, V L -- Siani, M A -- Sasaki, T -- Williams, T J -- Gray, P W -- Moore, P S -- Chang, Y -- Weiss, R A -- CA 67391/CA/NCI NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1997 Oct 10;278(5336):290-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9323208" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; CD4-Positive T-Lymphocytes/virology ; Chemokines/genetics/metabolism/pharmacology/*physiology ; Chemotaxis, Leukocyte ; Chick Embryo ; Eosinophils/physiology ; HIV-1/*physiology ; Herpesvirus 8, Human/*genetics/physiology ; Humans ; Leukocytes, Mononuclear/virology ; Macrophage Inflammatory Proteins/genetics/metabolism/pharmacology/*physiology ; Neovascularization, Pathologic/*etiology ; Neutrophils/physiology ; Receptors, CCR3 ; *Receptors, Chemokine ; Receptors, Cytokine/agonists/metabolism ; Receptors, HIV/metabolism ; Tumor Cells, Cultured ; *Viral Proteins ; Virus Replication
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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