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  • National Academy of Sciences  (51)
  • American Association for the Advancement of Science (AAAS)  (8)
  • 1
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    Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma [Neuroscience] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-03-16
    Description: Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive tumors of childhood that are almost universally fatal. Our understanding of this devastating cancer is limited by a dearth of available tissue for study and by the lack of a faithful animal model. Intriguingly, DIPGs are restricted to the ventral pons and occur during a narrow window of middle childhood, suggesting dysregulation of a postnatal neurodevelopmental process. Here, we report the identification of a previously undescribed population of immunophenotypic neural precursor cells in the human and murine brainstem whose temporal and spatial distributions correlate closely with the incidence of DIPG and highlight a candidate cell of origin. Using early postmortem DIPG tumor tissue, we have established in vitro and xenograft models and find that the Hedgehog (Hh) signaling pathway implicated in many developmental and oncogenic processes is active in DIPG tumor cells. Modulation of Hh pathway activity has functional consequences for DIPG self-renewal capacity in neurosphere culture. The Hh pathway also appears to be active in normal ventral pontine precursor-like cells of the mouse, and unregulated pathway activity results in hypertrophy of the ventral pons. Together, these findings provide a foundation for understanding the cellular and molecular origins of DIPG, and suggest that the Hh pathway represents a potential therapeutic target in this devastating pediatric tumor.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Friction anisotropy and asymmetry of a compliant monolayer induced by a small molecular tilt (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-04-29
    Description: Lateral force microscopy in the wearless regime was used to study the friction behavior of a lipid monolayer on mica. In the monolayer, condensed domains with long-range orientational order of the lipid molecules were present. The domains revealed unexpectedly strong friction anisotropies and non-negligible friction asymmetries. The angular dependency of these effects correlated well with the tilt direction of the alkyl chains of the monolayer, as determined by electron diffraction and Brewster angle microscopy. The molecular tilt causing these frictional effects was less than 15 degrees, demonstrating that even small molecular tilts can make a major contribution to friction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liley -- Gourdon -- Stamou -- Meseth -- Fischer -- Lautz -- Stahlberg -- Vogel -- Burnham -- Duschl -- New York, N.Y. -- Science. 1998 Apr 10;280(5361):273-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉M. Liley, D. Stamou, U. Meseth, H. Vogel, C. Duschl, Department of Chemistry, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland. D. Gourdon and N. A. Burnham, Department of Physics, Swiss Federal Institute of Technology, CH-1015.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9535654" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Invasive harlequin ladybird carries biological weapons against native competitors (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-21
    Description: Invasive species that proliferate after colonizing new habitats have a negative environmental and economic impact. The reason why some species become successful invaders, whereas others, even closely related species, remain noninvasive is often unclear. The harlequin ladybird Harmonia axyridis, introduced for biological pest control, has become an invader that is outcompeting indigenous ladybird species in many countries. Here, we show that Harmonia carries abundant spores of obligate parasitic microsporidia closely related to Nosema thompsoni. These microsporidia, while not harming the carrier Harmonia, are lethal pathogens for the native ladybird Coccinella septempunctata. We propose that intraguild predation, representing a major selective force among competing ladybird species, causes the infection and ultimate death of native ladybirds when they feed on microsporidia-contaminated Harmonia eggs or larvae.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vilcinskas, Andreas -- Stoecker, Kilian -- Schmidtberg, Henrike -- Rohrich, Christian R -- Vogel, Heiko -- New York, N.Y. -- Science. 2013 May 17;340(6134):862-3. doi: 10.1126/science.1234032.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Phytopathology and Applied Zoology, Heinrich-Buff-Ring 26-32, Justus-Liebig-University of Giessen, D-35392 Giessen, Germany. andreas.vilcinskas@agrar.uni-giessen.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23687046" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Beetles/*parasitology/*physiology ; *Food Chain ; Hemocytes/parasitology ; Hemolymph/parasitology ; *Introduced Species ; Nosema/*physiology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-04-15
    Description: Myelination of the central nervous system requires the generation of functionally mature oligodendrocytes from oligodendrocyte precursor cells (OPCs). Electrically active neurons may influence OPC function and selectively instruct myelination of an active neural circuit. In this work, we use optogenetic stimulation of the premotor cortex in awake, behaving mice to demonstrate that neuronal activity elicits a mitogenic response of neural progenitor cells and OPCs, promotes oligodendrogenesis, and increases myelination within the deep layers of the premotor cortex and subcortical white matter. We further show that this neuronal activity-regulated oligodendrogenesis and myelination is associated with improved motor function of the corresponding limb. Oligodendrogenesis and myelination appear necessary for the observed functional improvement, as epigenetic blockade of oligodendrocyte differentiation and myelin changes prevents the activity-regulated behavioral improvement.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096908/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096908/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibson, Erin M -- Purger, David -- Mount, Christopher W -- Goldstein, Andrea K -- Lin, Grant L -- Wood, Lauren S -- Inema, Ingrid -- Miller, Sarah E -- Bieri, Gregor -- Zuchero, J Bradley -- Barres, Ben A -- Woo, Pamelyn J -- Vogel, Hannes -- Monje, Michelle -- 1S10RR02678001/RR/NCRR NIH HHS/ -- K08 NS070926/NS/NINDS NIH HHS/ -- K08NS070926/NS/NINDS NIH HHS/ -- R01 EY10257/EY/NEI NIH HHS/ -- T32 MH020016/MH/NIMH NIH HHS/ -- UL1 RR025744/RR/NCRR NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 May 2;344(6183):1252304. doi: 10.1126/science.1252304. Epub 2014 Apr 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Neurology, Neurosurgery, and Pediatrics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24727982" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Thy-1/genetics ; Behavior, Animal/physiology ; *Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Corpus Callosum/cytology/physiology ; Mice ; Mice, Mutant Strains ; Motor Activity/physiology ; Motor Cortex/cytology/*physiology ; Myelin Sheath/*metabolism ; Nerve Fibers, Myelinated/*metabolism ; Neural Stem Cells/*physiology ; Neurons/*physiology ; Oligodendroglia/*cytology ; Rhodopsin/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Wagnerian genetics (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, H -- New York, N.Y. -- Science. 1995 Jan 27;267(5197):437.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7824939" target="_blank"〉PubMed〈/a〉
    Keywords: *Aggression ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Calcium-Calmodulin-Dependent Protein Kinases/deficiency/genetics ; *Drama ; *Fear ; Humans ; *Literature, Modern ; Male ; Mice ; Mice, Knockout
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    2.8 million years of Arctic climate change from Lake El'gygytgyn, NE Russia (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: The reliability of Arctic climate predictions is currently hampered by insufficient knowledge of natural climate variability in the past. A sediment core from Lake El'gygytgyn in northeastern (NE) Russia provides a continuous, high-resolution record from the Arctic, spanning the past 2.8 million years. This core reveals numerous "super interglacials" during the Quaternary; for marine benthic isotope stages (MIS) 11c and 31, maximum summer temperatures and annual precipitation values are ~4 degrees to 5 degrees C and ~300 millimeters higher than those of MIS 1 and 5e. Climate simulations show that these extreme warm conditions are difficult to explain with greenhouse gas and astronomical forcing alone, implying the importance of amplifying feedbacks and far field influences. The timing of Arctic warming relative to West Antarctic Ice Sheet retreats implies strong interhemispheric climate connectivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Melles, Martin -- Brigham-Grette, Julie -- Minyuk, Pavel S -- Nowaczyk, Norbert R -- Wennrich, Volker -- DeConto, Robert M -- Anderson, Patricia M -- Andreev, Andrei A -- Coletti, Anthony -- Cook, Timothy L -- Haltia-Hovi, Eeva -- Kukkonen, Maaret -- Lozhkin, Anatoli V -- Rosen, Peter -- Tarasov, Pavel -- Vogel, Hendrik -- Wagner, Bernd -- New York, N.Y. -- Science. 2012 Jul 20;337(6092):315-20. doi: 10.1126/science.1222135. Epub 2012 Jun 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Geology and Mineralogy, University of Cologne, Zuelpicher Strasse 49a, D-50674 Cologne, Germany. mmelles@uni-koeln.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22722254" target="_blank"〉PubMed〈/a〉
    Keywords: Arctic Regions ; *Climate Change ; *Cold Climate ; Geologic Sediments ; Ice Cover ; *Lakes ; Radiometric Dating ; Russia ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Response to comments on "Invasive harlequin ladybird carries biological weapons against native competitors" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-09-21
    Description: Comments by de Jong et al., Solter et al., and Sloggett question the ecological relevance of the abundant microsporidia found in the invasive ladybird Harmonia axyridis. We contend that there is abundant evidence that native ladybirds feed on H. axyridis eggs and that interspecific microsporidial transfer is a common phenomenon, supporting the proposed role of these parasites as biological weapons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vilcinskas, Andreas -- Stoecker, Kilian -- Schmidtberg, Henrike -- Rohrich, Christian R -- Vogel, Heiko -- New York, N.Y. -- Science. 2013 Sep 20;341(6152):1342. doi: 10.1126/science.1242484.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Phytopathology and Applied Zoology, Heinrich-Buff-Ring 26-32, Justus-Liebig-University of Giessen, D-35392 Giessen, Germany. andreas.vilcinskas@agrar.uni-giessen.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24052293" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Beetles/*parasitology/*physiology ; *Food Chain ; *Introduced Species ; Nosema/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Nogo-A is a negative regulator of CNS angiogenesis [Neuroscience] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-05-22
    Description: Nogo-A is an important axonal growth inhibitor in the adult and developing CNS. In vitro, Nogo-A has been shown to inhibit migration and cell spreading of neuronal and nonneuronal cell types. Here, we studied in vivo and in vitro effects of Nogo-A on vascular endothelial cells during angiogenesis of the...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Structure of neon hydrate [Chemistry] (2014)
    National Academy of Sciences
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    Publication Date: 2014-07-23
    Description: Neon hydrate was synthesized and studied by in situ neutron diffraction at 480 MPa and temperatures ranging from 260 to 70 K. For the first time to our knowledge, we demonstrate that neon atoms can be enclathrated in water molecules to form ice II-structured hydrates. The guest Ne atoms occupy...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 10
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    Antennal transcriptome of Manduca sexta (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-04-15
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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