Publication Date:
1986-01-03
Description:
Pf 155, a protein of the human malaria parasite Plasmodium falciparum, is strongly immunogenic in humans and is believed to be a prime candidate for the preparation of a vaccine. Human monoclonal antibodies to Pf 155 were obtained by cloning B cells that had been prepared from an immune donor and transformed with Epstein-Barr virus. When examined by indirect immunofluorescence, these antibodies stained the surface of infected erythrocytes, free merozoites, segmented schizonts, and gametocytes. They bound to a major polypeptide with a relative molecular weight of 155K and to two minor ones (135K and 120K), all having high affinity for human glycophorin. The antibodies strongly inhibited merozoite reinvasion in vitro, suggesting that they might be appropriate reagents for therapeutic administration in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Udomsangpetch, R -- Lundgren, K -- Berzins, K -- Wahlin, B -- Perlmann, H -- Troye-Blomberg, M -- Carlsson, J -- Wahlgren, M -- Perlmann, P -- Bjorkman, A -- New York, N.Y. -- Science. 1986 Jan 3;231(4733):57-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3510452" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal/*immunology/therapeutic use
;
Antigens, Protozoan/analysis/*immunology
;
Humans
;
Plasmodium falciparum/*immunology
;
Vaccines/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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