Publication Date:
1998-11-30
Description:
HOX genes specify cell fate in the anterior-posterior axis of animal embryos. Invertebrate chordates have one HOX cluster, but mammals have four, suggesting that cluster duplication facilitated the evolution of vertebrate body plans. This report shows that zebrafish have seven hox clusters. Phylogenetic analysis and genetic mapping suggest a chromosome doubling event, probably by whole genome duplication, after the divergence of ray-finned and lobe-finned fishes but before the teleost radiation. Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amores, A -- Force, A -- Yan, Y L -- Joly, L -- Amemiya, C -- Fritz, A -- Ho, R K -- Langeland, J -- Prince, V -- Wang, Y L -- Westerfield, M -- Ekker, M -- Postlethwait, J H -- P01HD22486/HD/NICHD NIH HHS/ -- R01RR10715/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1998 Nov 27;282(5394):1711-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9831563" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chromosome Mapping
;
Chromosomes/genetics
;
*Evolution, Molecular
;
Gene Duplication
;
*Genes, Homeobox
;
*Genome
;
Models, Genetic
;
*Multigene Family
;
Phylogeny
;
Pseudogenes
;
Zebrafish/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink