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  • American Association for the Advancement of Science (AAAS)  (357)
  • American Meteorological Society (AMS)
  • 1980-1984  (357)
  • 1981  (357)
  • 1
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    Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: A DNA sequence coding for the immunogenic capsid protein VP3 of foot-and-mouth disease virus A12, prepared from the virion RNA, was ligated to a plasmid designed to express a chimeric protein from the Escherichia coli tryptophan promoter-operator system. When Escherichia coli transformed with this plasmid was grown in tryptophan-depleted media, approximately 17 percent of the total cellular protein was found to be an insoluble and stable chimeric protein. The purified chimeric protein competed equally on a molar basis with VP3 for specific antibodies to foot-and-mouth disease virus. When inoculated into six cattle and two swine, this protein elicited high levels of neutralizing antibody and protection against challenge with foot-and-mouth disease virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kleid, D G -- Yansura, D -- Small, B -- Dowbenko, D -- Moore, D M -- Grubman, M J -- McKercher, P D -- Morgan, D O -- Robertson, B H -- Bachrach, H L -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1125-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272395" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibody Formation ; Base Sequence ; Cattle ; Cattle Diseases/*prevention & control ; *Cloning, Molecular ; DNA Restriction Enzymes ; DNA, Recombinant/metabolism ; Foot-and-Mouth Disease/*prevention & control ; Immunity, Cellular ; Protein Biosynthesis ; Swine ; Swine Diseases/*prevention & control ; Transcription, Genetic ; *Vaccines ; Viral Proteins/genetics/*therapeutic use
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Regulation of leucine metabolism in man: a stable isotope study (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: Leucine catabolism is regulated by either of the first two degradative steps: (reversible) transamination to the keto acid or subsequent decarboxylation. A method is described to measure rates of leucine transamination, reamination, and keto acid oxidation. The method is applied directly to humans by infusing the nonradioactive tracer, L-[15N,1-13C]leucine. Leucine transamination was found to be operating several times faster than the keto acid decarboxylation and to be of equal magnitude in adult human males under two different dietary conditions, postabsorptive and fed. These results indicate that decarboxylation, not transamination, is the rate-limiting step in normal human leucine metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matthews, D E -- Bier, D M -- Rennie, M J -- Edwards, R H -- Halliday, D -- Millward, D J -- Clugston, G A -- AM-25994/AM/NIADDK NIH HHS/ -- HD-10667/HD/NICHD NIH HHS/ -- RR-00954/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1129-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302583" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Carbon Isotopes ; Humans ; Kinetics ; Leucine/*metabolism ; Male ; Models, Biological ; Nitrogen Isotopes ; Oxidation-Reduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Planetary radio astronomy observations from voyager 1 near saturn (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-10
    Description: The Voyager 1 planetary radio astronomy experiment detected two distinct kinds of radio emissions from Saturn. The first, Saturn kilometric radiation, is strongly polarized, bursty, tightly correlated with Saturn's rotation, and exhibits complex dynamic spectral features somewhat reminiscent of those in Jupiter's radio emission. It appears in radio frequencies below about 1.2 megahertz. The second kind of radio emission, Saturn electrostatic discharge, is unpolarized, extremely impulsive, loosely correlated with Saturn's rotation, and very broadband, appearing throughout the observing range of the experiment (20.4 kilohertz to 40.2 megahertz). Its sources appear to lie in the planetary rings.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warwick, J W -- Pearce, J B -- Evans, D R -- Carr, T D -- Schauble, J J -- Alexander, J K -- Kaiser, M L -- Desch, M D -- Pedersen, M -- Lecacheux, A -- Daigne, G -- Boischot, A -- Barrow, C H -- New York, N.Y. -- Science. 1981 Apr 10;212(4491):239-43.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17783837" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Extreme ultraviolet observations from voyager 1 encounter with saturn (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-10
    Description: The global hydrogen Lyman alpha, helium (584 angstroms), and molecular hydrogen band emissions from Saturn are qualitatively similar to those of Jupiter, but the Saturn observations emphasize that the H(2) band excitation mechanism is closely related to the solar flux. Auroras occur near 80 degrees latitude, suggesting Earth-like magnetotail activity, quite different from the dominant Io plasma torus mechanism at Jupiter. No ion emissions have been detected from the magnetosphere of Saturn, but the rings have a hydrogen atmosphere; atomic hydrogen is also present in a torus between 8 and 25 Saturn radii. Nitrogen emission excited by particles has been detected in the Titan dayglow and bright limb scans. Enhancement of the nitrogen emission is observed in the region of interaction between Titan's atmosphere and the corotating plasma in Saturn's plasmasphere. No particle-excited emission has been detected from the dark atmosphere of Titan. The absorption profile of the atmosphere determined by the solar occultation experiment, combined with constraints from the dayglow observations and temperature information, indicate that N(2) is the dominant species. A double layer structure has been detected above Titan's limb. One of the layers may be related to visible layers in the images of Titan.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broadfoot, A L -- Sandel, B R -- Shemansky, D E -- Holberg, J B -- Smith, G R -- Strobel, D F -- McConnell, J C -- Kumar, S -- Hunten, D M -- Atreya, S K -- Donahue, T M -- Moos, H W -- Bertaux, J L -- Blamont, J E -- Pomphrey, R B -- Linick, S -- New York, N.Y. -- Science. 1981 Apr 10;212(4491):206-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17783831" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Hyperkeratosis induced by sunlight degradation products of the major polybrominated biphenyl in Firemaster (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-21
    Description: Sunlight photodegradation of 2,2', 4,4', 5,5' -hexabromobiphenyl, the major component of Firemaster, gave a mixture that produces severe hyperkeratosis of the rabbit ear. This component in its pure state does not cause hyperkeratosis. One or more of the four major photolysis products must be responsible for this activity. A similar photodegradation pattern was observed for 2,2', 3,4,4', 5,5' -heptabromobiphenyl, the second largest component of Firemaster.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patterson, D G -- Hill, R H -- Needham, L L -- Orti, D L -- Kimbrough, R D -- Liddle, J A -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):901-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6266016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biphenyl Compounds/radiation effects ; Chemical Industry ; Disease Models, Animal ; Environmental Exposure ; Keratosis/*chemically induced ; Michigan ; Photochemistry ; *Polybrominated Biphenyls/radiation effects ; Rabbits ; Sunlight
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Long-term infusion of glucose, beta-hydroxybutyrate, and glycerol into the third ventricle of the rat brain caused a stabilization of body weight at a lower than normal level. Among the glucose- and glycerol-treated animals this weight loss was caused in part by temporary hypophagia. Among the animals treated with beta-hydroxybutyrate the weight loss was unaccompanied by a reduction in food intake. The results are consistent with the view that the systems controlling food intake and body weight are sensitive to the availability of brain fuels. They are not consistent however, with the view that these control systems monitor calories independently of their source.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, J D -- Wirtshafter, D -- Asin, K E -- Brief, D -- AM 26030/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):81-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7193909" target="_blank"〉PubMed〈/a〉
    Keywords: 3-Hydroxybutyric Acid ; Animals ; *Appetite Regulation/drug effects ; *Body Weight/drug effects ; Brain/drug effects/*physiology ; Circadian Rhythm ; Drinking/drug effects ; *Eating/drug effects ; Glucose/*pharmacology ; Glycerol/*pharmacology ; Hydroxybutyrates/administration & dosage/*pharmacology ; Hypothalamus/drug effects ; Injections, Intraventricular ; Male ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Discovery of natural gain amplification in the 10-micrometer carbon dioxide laser bands on Mars: a natural laser (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Fully resolved intensity profiles of various lines in the carbon dioxide band at 10.4 micrometers have been measured on Mars with an infrared heterodyne spectrometer. Analysis of the line shapes shows that the Mars atmosphere exhibits positive gain in these lines. The detection of natural optical gain amplification enables identification of these lines as a definite natural laser.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mumma, M J -- Buhl, D -- Chin, G -- Deming, D -- Espenak, F -- Kostiuk, T -- Zipoy, D -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):45-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17747630" target="_blank"〉PubMed〈/a〉
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  • 8
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    Submillimeter heterodyne detection of interstellar carbon monoxide at 434 micrometers (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-06
    Description: A submillimeter heterodyne radiometer, developed for astronomical applications, uses an optically pumped laser local oscillator and a quasi-optical Schottky diode mixer. The resultant telescope-mounted system, which has a noise temperature less than 4000 K (double sideband) and high frequency and spatial resolution, has been used to detect the J = 6 --〉 5 rotational transition of carbon monoxide at 434 micrometers in the Orion molecular cloud. The measurements, when compared with previous millimeter-wave data, indicate that the broad carbon monoxide emission feature is produced by an optically thin gas whose temperature exceeds 180 K.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fetterman, H R -- Koepf, G A -- Goldsmith, P F -- Clifton, B J -- Buhl, D -- Erickson, N R -- Peck, D D -- McAvoy, N -- Tannenwald, P E -- New York, N.Y. -- Science. 1981 Feb 6;211(4482):580-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17840958" target="_blank"〉PubMed〈/a〉
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  • 9
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    R & d and productivity (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DE S Price, D -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1116.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17755133" target="_blank"〉PubMed〈/a〉
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  • 10
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    Persistent behavior at high rates maintained by intravenous self-administration of nicotine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: Squirrel monkeys pressed a level at high rates under a second-order schedule of reinforcement in which level pressing produced a brief visual stimulus that was occasionally contiguous with an intravenous injection of nicotine. The rate of lever pressing could be markedly reduced either by substituting saline for nicotine injections or by blocking the effects of nicotine with mecamylamine. The rate of level pressing could be reduced by eliminating the brief visual stimulus. These results show that nicotine can function as an effective reinforcer under a second-order schedule of drug self-administration and that an environmental stimulus associated with nicotine intake can contribute to the maintenance of persistent drug-seeking behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, S R -- Spealman, R D -- Goldberg, D M -- DA00499/DA/NIDA NIH HHS/ -- DA02658/DA/NIDA NIH HHS/ -- MH07658/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):573-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Humans ; Injections, Intravenous ; Nicotine/administration & dosage/*pharmacology ; Reinforcement (Psychology)/drug effects ; Saimiri ; Self Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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