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  • 1
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    Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-12-06
    Description: A polyamide nucleic acid (PNA) was designed by detaching the deoxyribose phosphate backbone of DNA in a computer model and replacing it with an achiral polyamide backbone. On the basis of this model, oligomers consisting of thymine-linked aminoethylglycyl units were prepared. These oligomers recognize their complementary target in double-stranded DNA by strand displacement. The displacement is made possible by the extraordinarily high stability of the PNA-DNA hybrids. The results show that the backbone of DNA can be replaced by a polyamide, with the resulting oligomer retaining base-specific hybridization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nielsen, P E -- Egholm, M -- Berg, R H -- Buchardt, O -- New York, N.Y. -- Science. 1991 Dec 6;254(5037):1497-500.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry B, Panum Institute, Copenhagen, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1962210" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Molecular Sequence Data ; Molecular Structure ; Nylons/*chemistry ; Oligonucleotides/*chemistry ; Photochemistry ; Thermodynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Extensive arsenic contamination in high-pH unconfined aquifers in the Indus Valley (2017)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2017-08-24
    Description: Arsenic-contaminated aquifers are currently estimated to affect ~150 million people around the world. However, the full extent of the problem remains elusive. This is also the case in Pakistan, where previous studies focused on isolated areas. Using a new data set of nearly 1200 groundwater quality samples throughout Pakistan, we have created state-of-the-art hazard and risk maps of arsenic-contaminated groundwater for thresholds of 10 and 50 μg/liter. Logistic regression analysis was used with 1000 iterations, where surface slope, geology, and soil parameters were major predictor variables. The hazard model indicates that much of the Indus Plain is likely to have elevated arsenic concentrations, although the rest of the country is mostly safe. Unlike other arsenic-contaminated areas of Asia, the arsenic release process in the arid Indus Plain appears to be dominated by elevated-pH dissolution, resulting from alkaline topsoil and extensive irrigation of unconfined aquifers, although pockets of reductive dissolution are also present. We estimate that approximately 50 million to 60 million people use groundwater within the area at risk, with hot spots around Lahore and Hyderabad. This number is alarmingly high and demonstrates the urgent need for verification and testing of all drinking water wells in the Indus Plain, followed by appropriate mitigation measures.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Lateral isotopic discontinuity in the lower crust: an example from antarctica (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-09-04
    Description: The lower continental crust is one of the least known variables in the crust-mantle evolutionary equation. In order to study the nature and compositional heterogeneity of the lower crust, more than 20 inclusions of lower crustal granulites in volcanic rocks from the McMurdo Sound region of Antarctica were analyzed for strontium and oxygen isotopes. These inclusions were erupted from volcanic centers covering an area of 12,000 square kilometers. Along with results from analyses of major and trace elements, the isotopic data reveal a profound discontinuity in the composition and probably the age of the lower crust that coincides with the boundary between the Transantarctic Mountains and the Ross Embayment. Although this topographic boundary between East and West Antarctica is largely a Cenozoic development, which apparently reflects a simple subvertical faulting relationship due to crustal rifting, the isotopic differences in the lower crust across the boundary suggest that the current faulting and rifting may coincide with an older crustal suture, the age of which is uncertain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalamarides, R I -- Berg, J H -- Hank, R A -- New York, N.Y. -- Science. 1987 Sep 4;237(4819):1192-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17801643" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Response thresholds in bacterial chemotaxis (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-10-18
    Description: Stimulation of Escherichia coli by exponential ramps of chemoattractants generates step changes in the concentration of the response regulator, CheY-P. Because flagellar motors are ultrasensitive, this should change the fraction of time that motors spin clockwise, the CW bias . However, early work failed to show changes in CW bias when ramps were shallow. This was explained by a model for motor remodeling that predicted plateaus in plots of CW bias versus [CheY-P]. We looked for these plateaus by examining distributions of CW bias in populations of cells with different mean [CheY-P]. We did not find such plateaus. Hence, we repeated the work on shallow ramps and found that motors did indeed respond. These responses were quantitatively described by combining motor remodeling with ultrasensitivity in a model that exhibited high sensitivities over a wide dynamic range.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    The bacterium has landed (2017)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2017-10-27
    Keywords: Microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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