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  • American Association for the Advancement of Science (AAAS)  (496)
  • 1975-1979  (496)
  • 1
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    Atmospheric reactions of polycyclic aromatic hydrocarbons: facile formation of mutagenic nitro derivatives (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-03
    Description: Directly active mutagens are formed on exposure of the promutagen benzo[a]pyrene to gaseous pollutants in smog. In simulated atmospheres containing 1 part per million nitrogen dioxide and traces of nitric acid, directly mutagenic nitro derivatives are readily formed from both benzo[a]pyrene and perylene, a non-mutagen in the Ames reversion assay. Possible formation of direct mutagens by such reactions on sample collection filters, in exhaust effluents, and in the atmosphere should be recognized.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pitts, J N Jr -- Van Cauwenberghe, K A -- Grosjean, D -- Schmid, J P -- Fitz, D R -- Belser, W L -- Knudson, G P -- Hynds, P M -- New York, N.Y. -- Science. 1978 Nov 3;202(4367):515-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705341" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; Benzopyrenes ; *Mutagens ; Nitrogen Dioxide ; Oxidation-Reduction ; Perylene ; Photochemistry ; *Polycyclic Compounds
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Visual phenomena induced by relativistic carbon ions with and without Cerenkov radiation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: Exposing the human eye to individual carbon ions (6C+) moving at relativistic speeds results in visual phenomena that include point flashes, streaks, and larger diffuse flashes. The diffuse flashes have previously been observed by astronauts in space but not in laboratory experiments with particles of high atomic number and energy. They are observed only when the nucleus moves fast enough to generate Cerenkov radiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNulty, P J -- Pease, V P -- Bond, V P -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):341-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663660" target="_blank"〉PubMed〈/a〉
    Keywords: *Carbon ; Cations, Monovalent ; Humans ; Motion ; *Space Flight ; Vision, Ocular/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Fluorine Is a Major Constituent of the Marine Sponge Halichondria moorei (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Fluorine constitutes about 10 percent of the dry weight of the marine sponge Halichondria moorei. The fluorine occurs as potassium fluorosilicate, which is a potent anti-inflammatory agent. A closely related sponge living in the same habitat does not contain any fluorine. The habitat was found to be free of fluorine except for the small amount naturally present in seawater.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gregson, R P -- Baldo, B A -- Thomas, P G -- Quinn, R J -- Bergquist, P R -- Stephens, J F -- Horne, A R -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1108-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17787487" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Sex pheromone of the tsetse fly: isolation, identification, and synthesis of contact aphrodisiacs (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-25
    Description: Sex pheromones isolated from the cuticle of the female tsetse fly, Glossina morsitans morsitans Westwood, release mating behavior in the male fly at ultrashort range or upon contact with baited decoys. Three active components were identified as 15,19-dimethylheptatriacontane, 17,21-dimethylheptatriacontane, and 15,19,23-trimethylheptatriacontane. Chemical and biological comparisons show that the natural and synthetic compounds are identical.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlson, D A -- Langley, P A -- Huyton, P -- New York, N.Y. -- Science. 1978 Aug 25;201(4357):750-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675256" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Female ; Male ; Pheromones/*isolation & purification ; Sex Attractants/chemical synthesis/*isolation & purification/pharmacology ; Sexual Behavior, Animal/drug effects ; Tsetse Flies/*analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Selective inhibition of tubulin synthesis by amiprophos methyl during flagellar regeneration in Chlamydomonas reinhardi (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-27
    Description: Amiprophos methyl (APM) is a strong, readily reversible and highly selective inhibitor of tubulin synthesis in Chlamydomonas reinhardi. The extensive induction of tubulin synthesis that accompanies flagellar regeneration in this organism is prevented by 3 to 10 micrometerAPM. When applied after induction has begun, APM causes a rapid cessation of tubulin synthesis. Translation studies in vitro indicate that the lack of tubulin production in APM-treated cells is not due to a direct inhibition of tubulin messenger RNA translation but rather to a selective depletion of tubulin messenger RNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collis, P S -- Weeks, D P -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):440-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/568309" target="_blank"〉PubMed〈/a〉
    Keywords: Chlamydomonas/ultrastructure ; Depression, Chemical ; Female ; Flagella/physiology/ultrastructure ; Glycoproteins/*biosynthesis ; Organothiophosphorus Compounds/*pharmacology ; Protein Biosynthesis ; Regeneration/drug effects ; Tubulin/*biosynthesis ; Zygote/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Chemical evolution from hydrogen cyanide: photochemical decarboxylation of orotic acid and orotate derivatives (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: Irradiation of solutions at pH 7 to pH 8.5 of orotic acid, orotidine, and orotidine 5'-phosphate with light at 254 nanometers yields the corresponding uracil derivative via the singlet excited state. This reaction completes a plausible prebiotic synthesis of uracil and its derivatives starting from HCN as the only carbon source.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferris, J P -- Joshi, P C -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):361-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208152" target="_blank"〉PubMed〈/a〉
    Keywords: Decarboxylation ; *Hydrogen Cyanide ; *Orotic Acid/analogs & derivatives ; Photochemistry ; Ribonucleotides ; Uracil/chemical synthesis ; Uridine/analogs & derivatives/chemical synthesis ; Uridine Monophosphate/chemical synthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Lancefield swamp and the extinction of the Australian megafauna (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-02
    Description: Excavations into the Australian swamp of Lancefield show that a bone bed dated at 26,000 years ago contains perhaps 10,000 giant extinct animals. Associated artifacts suggest that humans were in the area, but the direct cause of death of the animals is, on present evidence, not explicable. Such a recent date for the classic megafauna shows that it was living together with humans for at least 7000 years in southeast Australia. This enduring association argues against a catastrophic and rapid overkill in the Australian Pleistocene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gillespie, R -- Horton, D R -- Ladd, P -- Macumber, P G -- Rich, T H -- Thorne, R -- Wright, R V -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1044-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17740695" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Oral cocaine: plasma concentrations and central effects (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-14
    Description: Cocaine (2.0 milligrams per kilogram) given by the oral route is at least as effective as the same dose given intranasally. Cocaine is not detected in the plasma until 30 minutes after oral administration, but peak plasma concentrations are similar after both routes. The subjective "highs" in man are greater after oral than after intranasal administration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Dyke, C -- Jatlow, P -- Ungerer, J -- Barash, P G -- Byck, R -- New York, N.Y. -- Science. 1978 Apr 14;200(4338):211-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24895" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intranasal ; Administration, Oral ; Adult ; Cocaine/*administration & dosage/blood/pharmacology ; Euphoria/drug effects ; Humans ; Hydrogen-Ion Concentration ; Intestinal Absorption ; Male ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Gamma rays: further evidence for lack of a threshold dose for lethality to human cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: In experiments designed to measure human cell survival sith +/- 2 percent accuracy it was found that low doses (21 to 87 rad) of gamma-rays inactivated the colony-forming ability of cultured human cells with a probability of 0.00226 +/- 0.00012 per rad. There appears to be no threshold for the lethality of radiation to human cells in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Furcinitti, P S -- Todd, P -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):475-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504991" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/radiation effects ; Cell Survival/*radiation effects ; Cells, Cultured/radiation effects ; Dose-Response Relationship, Radiation ; *Gamma Rays ; Humans ; *Radiation, Ionizing
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    A cephalopod (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graziadei, P P -- New York, N.Y. -- Science. 1979 May 4;204(4392):492-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17819949" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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