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  • American Association for the Advancement of Science (AAAS)  (733)
  • 1975-1979  (733)
  • 1
    Publication Date: 1978-09-29
    Description: Owl monkeys were inoculated intracerebrally, subcutaneously, and intravenously with JC, BK, or SV40 virus. Two of four adult owl monkeys inoculated with JC virus, a human polyomavirus, developed brain tumors at 16 and 25 months after inoculation, respectively. A grade 3 to grade 4 astrocytoma (resembling a human glioblastoma multiforme) was found in the left cerebral hemisphere and brainstem of one monkey. The second monkey developed a malignant tumor in the left cerebral hemisphere containing both glial and neuronal cell types. Impression smears prepared from unfixed tissue of this tumor showed cells that contained polyomavirus T antigen. Virion antigens were not detected. Tumor cells cultured in vitro also contained T antigen but were negative for virion antigen. Infectious virus was not isolated from extracts of this tumor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉London, W T -- Houff, S A -- Madden, D L -- Fuccillo, D A -- Gravell, M -- Wallen, W C -- Palmer, A E -- Sever, J L -- Padgett, B L -- Walker, D L -- ZuRhein, G M -- Ohashi, T -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1246-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/211583" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Viral/analysis ; Antigens, Viral/analysis ; Brain Neoplasms/*etiology/pathology ; Immunosuppression ; Neoplasms, Experimental/etiology/pathology ; *Polyomavirus/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1979-05-11
    Description: SOLTRAN is a flexible computer model for the direct solar beam intensity spectrum at the earth's surface. It has been derived by combining the extra-terrestrial solar spectrum with the atmospheric transmittance spectrum. Application of SOLTRAN to the calculation of the potential efficiency of photovoltaic cells demonstrates the effect of atmospheric absorption bands. These bands prevent unequivocal assignment of optimum energy gap values.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ireland, P J -- Wagner, S -- Kazmerski, L L -- Hulstrom, R L -- New York, N.Y. -- Science. 1979 May 11;204(4393):611-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17839483" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1978-10-06
    Description: Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similiar to those of 45,X women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉German, J -- Simpson, J L -- Chaganti, R S -- Summitt, R L -- Reid, L B -- Merkatz, I R -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):53-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567843" target="_blank"〉PubMed〈/a〉
    Keywords: Disorders of Sex Development/embryology/*genetics ; Female ; Humans ; Karyotyping ; Male ; Ovary/embryology ; Pedigree ; Sex Chromosome Aberrations/embryology ; Testis/embryology ; Turner Syndrome/embryology/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 1979-12-21
    Description: The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, L L -- Markman, M H -- Wolfson, L I -- Dvorkin, B -- Warner, C -- Katzman, R -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505015" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Brain Mapping ; Catecholamines/pharmacology ; Dopamine/pharmacology ; Enzyme Activation/drug effects ; Extrapyramidal Tracts/*metabolism/ultrastructure ; Glucose/metabolism ; Male ; Mesencephalon/*metabolism ; Neurons/metabolism ; Rats ; Receptors, Dopamine/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-23
    Description: Cultured skin fibroblasts from subjects with cystic fibrosis exhibited normal population doubling times in early passages. After about 13 cumulative population doublings, cystic fibrosis lines doubled more slowly than controls and ceased doubling after about 19 weekly passages. Control lines continued doubling for 27 passages. The premature senescence noted in cells from subjects with cystic fibrosis reconciles controversial observations of cell doubling reported in the literature. Data presented here demonstrate that experiments with cystic fibrosis cells in late passage may generate misleading results since differences from control lines may be ascribed to generalized senile changes rather than to specific results of the cystic fibrosis genotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, B L -- Lam, L F -- Fast, L H -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1251-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424752" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aging ; Cell Division ; *Cell Survival ; Cells, Cultured ; Child ; Cystic Fibrosis/*pathology ; DNA/biosynthesis ; Female ; Humans ; Male ; Skin/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1978-03-31
    Description: Mouse spinal neurons grown in tissue culture were used to study the electrophysiological pharmacology of the opiate peptide leucine-enkephalin. Enkephalin depressed glutamate-evoked responses in a noncompetitive manner independent of any other effects on membrane properties. The results demonstrate a neuromodulatory action of opiate peptide functionally distinct from the conventional neurotransmitter class of operation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, J L -- Neale, J H -- Smith, T G Jr -- Macdonald, R L -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1451-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204016" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Endorphins/*pharmacology ; Enkephalins/antagonists & inhibitors/*pharmacology ; Excitatory Amino Acid Antagonists ; Glutamates/*pharmacology ; Iontophoresis ; Naloxone/pharmacology ; Neurons/*drug effects ; Spinal Cord ; Synapses/*drug effects ; Synaptic Transmission/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barrell, L L -- Rao, K N -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1083.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17830303" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 8
    Publication Date: 1978-03-24
    Description: Glucan is a potent reticuloendothelial stimulant whose immunobiological activity is mediated, in part, by an increase in the number and function of macrophages. In studying the role of glucan as a mediator of antibacterial activity, we attempted to ascertain the ability of glucan to modify the mortality of mice with experimentally induced Gram-positive bacteremia, and to enhance antibacterial defenses in rats as denoted by serum lysozyme and phagocytic activity. After intravenous administration of glucan, serum lysozyme concentrations were increased approximately sevenfold over control concentrations. The increase in serum lysozyme appeared to parallel the glucan-induced increase in phagocytosis and induced hyperplasia of macrophages. Prior treatment of mice with glucan significantly enhanced their survival when they were challenged systemically with Staphylococcus aureus. These studies indicate that glucan confers an enhanced state of host defense against bacterial infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kokoshis, P L -- Williams, D L -- Cook, J A -- Di Luzio, N R -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1340-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628841" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteriolysis/drug effects ; Immunotherapy ; Macrophages/drug effects ; Male ; Muramidase/*blood ; Phagocytosis/*drug effects ; Polysaccharides/*pharmacology/therapeutic use ; Rats ; Sepsis/prevention & control ; Staphylococcal Infections/*prevention & control/therapy ; Staphylococcus aureus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 1978-05-19
    Description: Barbiturate anesthetics, but not anticonvulsants, abolish the spontaneous activity of cultured spinal cord neurons; directly increase membrane conductance, an effect which is suppressed by the gamma-aminobutyric acid (GABA) antagonists picrotoxin and penicillin; and are more potent than anticonvulsants in augmenting GABA and depressing glutamate responses. Barbiturate anticonvulsants abolish picrotoxin-induced convulsive activity. These results indicate qualitative and quantitative differences between anesthetic and anticonvulsant barbiturates, which may explain their different clinical effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macdonald, R L -- Barker, J L -- New York, N.Y. -- Science. 1978 May 19;200(4343):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205953" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Cells, Cultured ; Electric Conductivity ; Glutamates/pharmacology ; Membrane Potentials/drug effects ; Neurons/*drug effects ; Pentobarbital/*pharmacology ; Phenobarbital/*pharmacology ; Picrotoxin/pharmacology ; Receptors, Neurotransmitter/drug effects ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 1979-06-01
    Description: Observations of the optical extreme ultraviolet spectrum of the Jupiter planetary system during the Voyager 1 encounter have revealed previously undetected physical processes of significant proportions. Bright emission lines of S III, S IV, and O III indicating an electron temperature of 10(5) K have been identified in preliminary analyses of the Io plasma torus spectrum. Strong auroral atomic and molecular hydrogen emissions have been observed in the polar regions of Jupiter near magnetic field lines that map the torus into the atmosphere of Jupiter. The observed resonance scattering of solar hydrogen Lyman alpha by the atmosphere of Jupiter and the solar occultation experiment suggest a hot thermosphere (〉/= 1000 K) wvith a large atomic hydrogen abundance. A stellar occultation by Ganymede indicates that its atmosphere is at most an exosphere.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broadfoot, A L -- Belton, M J -- Takacs, P Z -- Sandel, B R -- Shemansky, D E -- Holberg, J B -- Ajello, J M -- Atreya, S K -- Donahue, T M -- Moos, H W -- Bertaux, J L -- Blamont, J E -- Strobel, D F -- McConnell, J C -- Dalgarno, A -- Goody, R -- McElroy, M B -- New York, N.Y. -- Science. 1979 Jun 1;204(4396):979-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17800434" target="_blank"〉PubMed〈/a〉
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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