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  • American Association for the Advancement of Science (AAAS)  (94)
  • Elsevier
  • 1985-1989  (108)
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Keywords
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Year
  • 1
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    Structure and function of human amphiregulin: a member of the epidermal growth factor family (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-02-24
    Description: The complete amino acid sequence of amphiregulin, a bifunctional cell growth modulator, was determined. The truncated form contains 78 amino acids, whereas a larger form of amphiregulin contains six additional amino acids at the amino-terminal end. The amino-terminal half of amphiregulin is extremely hydrophilic and contains unusually high numbers of lysine, arginine, and asparagine residues. The carboxyl-terminal half of amphiregulin (residues 46 to 84) exhibits striking homology to the epidermal growth factor (EGF) family of proteins. Amphiregulin binds to the EGF receptor but not as well as EGF does. Amphiregulin fully supplants the requirement for EGF or transforming growth factor-alpha in murine keratinocyte growth, but it is a much weaker growth stimulator in other cell systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shoyab, M -- Plowman, G D -- McDonald, V L -- Bradley, J G -- Todaro, G J -- New York, N.Y. -- Science. 1989 Feb 24;243(4894 Pt 1):1074-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oncogen, Seattle, WA 98121.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2466334" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amphiregulin ; Animals ; Binding, Competitive ; Cell Division ; EGF Family of Proteins ; Epidermal Growth Factor/physiology ; Epidermis/cytology ; Glycoproteins/*physiology ; Growth Substances/*physiology ; Humans ; *Intercellular Signaling Peptides and Proteins ; Keratins/metabolism ; Mice ; Molecular Sequence Data ; Radioligand Assay ; Receptor, Epidermal Growth Factor/metabolism ; Sequence Homology, Nucleic Acid ; Transforming Growth Factors/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Circadian system controlling release of sperm in the insect testes (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-09-08
    Description: Release of mature sperm from the testis into seminal ducts of the gypsy moth exhibits a circadian rhythm. The rhythm of sperm release was shown to persist in vitro, in isolated complexes of testis and seminal ducts cultured in light-dark cycles or in constant darkness. The phase of the rhythm was also reset in vitro by exposure to shifted light-dark cycles. Therefore, the testis-seminal ducts complex from the gypsy moth is photosensitive and contains a circadian pacemaker, which controls the rhythm of sperm movement. This finding extends the range of structures in multicellular organisms that are known to contain circadian oscillators and provides a new model system in which circadian mechanisms may be studied.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giebultowicz, J M -- Riemann, J G -- Raina, A K -- Ridgway, R L -- New York, N.Y. -- Science. 1989 Sep 8;245(4922):1098-100.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17838810" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Growth of greenland ice sheet: measurement (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-12-22
    Description: Measurements of ice-sheet elevation change by satellite altimetry show that the Greenland surface elevation south of 72 degrees north latitude is increasing. The vertical velocity of the surface is 0.20 +/- 0.06 meters per year from measured changes in surface elevations at 5906 intersections between Geosat paths in 1985 and Seasat in 1978, and 0.28 +/- 0.02 meters per year from 256,694 intersections of Geosat paths during a 548-day period of 1985 to 1986.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zwally, H J -- Bindschadler, R A -- Brenner, A C -- Major, J A -- Marsh, J G -- New York, N.Y. -- Science. 1989 Dec 22;246(4937):1587-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17834422" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Thermomolecular pressure in surface melting: motivation for frost heave (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-12-22
    Description: A thermomolecular pressure is associated with surface melting, and it can drive mass flow along an interface under a lateral temperature gradient. The pressure is a universal thermodynamic function in the limit of thick films. It may be responsible for frost heave in frozen ground.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dash, J G -- New York, N.Y. -- Science. 1989 Dec 22;246(4937):1591-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17834424" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 5
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    North Carolina climate changes reconstructed from tree rings: a.d. 372 to 1985 (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-06-10
    Description: Millennium-old bald cypres trees (Taxodium distichum [(L.) Rich.] have ben used to develop a 1614-year reconstruction of the June Palmer drought severity index for North Carolina. This proxy paleoclimatic record indicates that the growing season climate of North Carolina has undergone many changes between significantly different regimes of drought and wetness that persist for approximately 30 years. Alternating wet and dry regimes were particularly well developed during the Medieval Warm Epoch (A.D. 1000 to 1300). The record June droughts in 1985 and 1986 and the preceding three decades of much wetter than average conditions both appear to have been rare climatic events, equaled only five times each since A.D. 372.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stahle, D W -- Cleaveland, M K -- Hehr, J G -- New York, N.Y. -- Science. 1988 Jun 10;240(4858):1517-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17798982" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Oxytocin secretion in response to cholecystokinin and food: differentiation of nausea from satiety (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-06-13
    Description: Administration of cholecystokinin (CCK) to rats caused a dose-dependent increase in plasma levels of the neurohypophyseal hormone oxytocin (OT). The OT secretion was comparable to that found in response to nausea-producing chemical agents that cause learned taste aversions. The effect of CCK on OT secretion was blunted after gastric vagotomy, as was the inhibition of food intake induced by CCK. Food ingestion also led to elevated plasma OT in rats, but CCK and aversive agents caused even greater OT stimulation. Thus, after administration of large doses of CCK, vagally mediated activation of central nausea pathways seems to be predominantly responsible for the subsequent decrease in food intake. Despite their dissimilar affective states, both nausea and satiety may activate a common hypothalamic oxytocinergic pathway that controls the inhibition of ingestion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Verbalis, J G -- McCann, M J -- McHale, C M -- Stricker, E M -- AM-16166/AM/NIADDK NIH HHS/ -- MH-25140/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1986 Jun 13;232(4756):1417-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3715453" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/physiology ; Cholecystokinin/*pharmacology ; Feeding Behavior/*physiology ; Nausea/*physiopathology ; Oxytocin/*secretion ; Paraventricular Hypothalamic Nucleus/physiology ; Rats ; Satiation/*physiology ; Vagotomy
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  • 7
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    Superconductivity in Alkaline Earth-Substituted La2CuO4-y (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-04-03
    Description: La(2)CuO4-y ceramics containing a few percent of Ca(2+), Sr(2+), and Ba(2+) ions have been prepared. Resistivity and susceptibility measurements exhibit superconductive onsets (as in earlier Ba(2+)-containing samples). The onset temperature La(2)CuO4-y with Sr(2+) is higher and its superconductivity-induced diamagnetism larger than that found with Ba(2+) and Ca(2+). This is proof that the electronic change resulting from alkaline earthdoping, rather than the size effect, is responsible for superconductivity. The ionic radius of Sr(2+) is close to that of La(3+) for which it presumably substitutes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bednorz, J G -- Muller, K A -- Takashige, M -- New York, N.Y. -- Science. 1987 Apr 3;236(4797):73-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17759207" target="_blank"〉PubMed〈/a〉
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  • 8
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    The adenovirus major late transcription factor activates the rat gamma-fibrinogen promoter (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-10-30
    Description: The major late transcription factor (MLTF) is a 46-kilodalton polypeptide that specifically binds to and activates transcription from the major late promoter of adenovirus. The presence of this promoter-specific transcription factor in uninfected HeLa cell extracts suggests that MLTF is also involved in the transcription of cellular genes. This report demonstrates that MLTF specifically stimulates transcription of the rat gamma-fibrinogen gene through a high-affinity binding site. Stimulation of transcription by MLTF was not dependent on the exact position of the MLTF binding site with respect either to the transcription initiation site or to adjacent promoter elements. These results suggest that one of the cellular functions of MLTF is to control gamma-fibrinogen gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chodosh, L A -- Carthew, R W -- Morgan, J G -- Crabtree, G R -- Sharp, P A -- P01-CA42063/CA/NCI NIH HHS/ -- P30-CA14051/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Oct 30;238(4827):684-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3672119" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/*genetics ; Animals ; DNA-Binding Proteins/*genetics ; Fibrinogen/*genetics ; *Gene Expression Regulation ; *Promoter Regions, Genetic ; RNA Polymerase II/metabolism ; Rats ; Regulatory Sequences, Nucleic Acid ; Transcription Factors/*genetics ; Transcription, Genetic ; Viral Proteins/genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    The discovery of a class of high-temperature superconductors (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-09-04
    Description: The exceptional interest in the new class of oxide superconductors and the importance of these materials are discussed together with the concepts that led to their discovery. The discovery itself and its early confirmation are summarized, including the work until the beginning of 1987. The observation of a superconductive glass state in percolative samples is also discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muller, K A -- Bednorz, J G -- New York, N.Y. -- Science. 1987 Sep 4;237(4819):1133-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17801637" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 10
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    Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-08-14
    Description: Thousands of pet cats die each year with dilated cardiomyopathy, the cause of which is unknown. Although taurine is present in millimolar concentrations in the myocardium of all mammals, taurine depletion has not previously been associated with a decrease in myocardial function in any species. In this study, low plasma taurine concentrations associated with echocardiographic evidence of myocardial failure were observed in 21 cats fed commercial cat foods and in 2 of 11 cats fed a purified diet containing marginally low concentrations of taurine for 4 years. Oral supplementation of taurine resulted in increased plasma taurine concentrations and was associated with normalization of left ventricular function in both groups of cats. Since myocardial concentrations of taurine are directly related to plasma concentrations and low plasma concentrations were found to be associated with myocardial failure in cats, a direct link between decreased taurine concentration in the myocardium and decreased myocardial mechanical function is proposed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pion, P D -- Kittleson, M D -- Rogers, Q R -- Morris, J G -- New York, N.Y. -- Science. 1987 Aug 14;237(4816):764-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3616607" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cardiomyopathy, Dilated/diagnosis/etiology/*veterinary ; *Cat Diseases ; Cats ; Dogs ; Echocardiography ; Humans ; Myocardium/metabolism ; Retinal Degeneration/etiology/veterinary ; Taurine/blood/*deficiency/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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