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  • 1
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    Stabilizing heterostructures of soft perovskite semiconductors (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Here we report a solution-processing strategy to stabilize the perovskite-based heterostructure. Strong Pb–Cl and Pb–O bonds formed between a [CH(NH〈sub〉2〈/sub〉)〈sub〉2〈/sub〉]〈i〉〈sub〉x〈/sub〉〈/i〉[CH〈sub〉3〈/sub〉NH〈sub〉3〈/sub〉]〈sub〉1–〈/sub〉〈i〉〈sub〉x〈/sub〉〈/i〉Pb〈sub〉1+〈/sub〉〈i〉〈sub〉y〈/sub〉〈/i〉I〈sub〉3〈/sub〉 film with a Pb-rich surface and a chlorinated graphene oxide layer. The constructed heterostructure can selectively extract photogenerated charge carriers and impede the loss of decomposed components from soft perovskites, thereby reducing damage to the organic charge-transporting semiconductors. Perovskite solar cells with an aperture area of 1.02 square centimeters maintained 90% of their initial efficiency of 21% after operation at the maximum power point under AM1.5G solar light (100 milliwatts per square centimeter) at 60°C for 1000 hours. The stabilized output efficiency of the aged device was further certified by an accredited test center.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The immunoproteasome catalytic {beta}5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. The immunoproteasome is an inducible form of the proteasome that is intimately involved in inflammatory diseases. Here, we found that the expression and activity of immunoproteasome catalytic subunit β5i were significantly up-regulated in angiotensin II (Ang II)–treated cardiomyocytes and in the hypertrophic hearts. Knockout of β5i in cardiomyocytes and mice markedly attenuated the hypertrophic response, and this effect was aggravated by β5i overexpression in cardiomyocytes and transgenic mice. Mechanistically, β5i interacted with and promoted ATG5 degradation thereby leading to inhibition of autophagy and cardiac hypertrophy. Further, knockdown of ATG5 or inhibition of autophagy reversed the β5i knockout-mediated reduction of cardiomyocyte hypertrophy induced by Ang II or pressure overload. Together, this study identifies a novel role for β5i in the regulation of cardiac hypertrophy. The inhibition of β5i activity may provide a new therapeutic approach for hypertrophic diseases.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Anti-parity-time symmetry in diffusive systems (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Various concepts related to parity-time symmetry, including anti–parity-time symmetry, have found broad applications in wave physics. Wave systems are fundamentally described by Hermitian operators, whereas their unusual properties are introduced by incorporation of gain and loss. We propose that the related physics need not be restricted to wave dynamics, and we consider systems described by diffusive dynamics. We study the heat transfer in two countermoving media and show that this system exhibits anti–parity-time symmetry. The spontaneous symmetry breaking results in a phase transition from motionless temperature profiles, despite the mechanical motion of the background, to moving temperature profiles. Our results extend the concepts of parity-time symmetry beyond wave physics and may offer opportunities to manipulate heat and mass transport.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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