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  • Springer  (2)
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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Molecular and cellular biochemistry 174 (1997), S. 321-324 
    ISSN: 1573-4919
    Schlagwort(e): ageing ; skeletal muscle ; bioenergetics ; 31P MRS ; mitochondrial function
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract 31P magnetic resonance spectroscopy studies were carried out on calf muscle of 144 normal male and female subjects age 20–83 years in order to investigate age-related changes in muscle metabolism. Compared to the young adults (20–29 years), oxidative capacity was higher in the children (6–12 years) and was significantly decreased in the elderly (70–83 years). In the adults, the intracellular pH change during exercise diminished with increasing age, resulting in higher calculated free [ADP] and possibly serving as an adaptive mechanism to stimulate mitochondrial ATP production. Children also had higher pH and [ADP] in exercise, but unlike results from the elderly, this was associated with higher oxidative capacity and more rapid metabolic recovery from exercise. (Mol Cell Biochem 174: 321–324, 1997)
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    ISSN: 1573-4919
    Schlagwort(e): adenine nucleotide translocase ; creatine kinase ; diffusion ; mitochondrion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract We describe a model of mitochondrial regulation in vivo which takes account of spatial diffusion of high-energy (ATP and phosphocreatine) and low-energy metabolites (ADP and creatine), their interconversion by creatine kinase (which is not assumed to be at equilibrium), and possible functional 'coupling' between the components of creatine kinase associated with the mitochondrial adenine nucleotide translocase and the myofibrillar ATPase. At high creatine kinase activity, the degree of functional coupling at either the mitochondrial or ATPase end has little effect on relationships between oxidative ATP synthesis rate and spatially-averaged metabolite concentrations. However, lowering the creatine kinase activity raises the mean steady state ADP and creatine concentrations, to a degree which depends on the degree of coupling. At high creatine kinase activity, the fraction of flow carried by ATP is small. Lowering the creatine kinase activity raises this fraction, especially when there is little functional coupling. All metabolites show small spatial gradients, more so at low cytosolic creatine kinase activity, and unless there is near-complete coupling, so does net creatine kinase flux. During workjump transitions, spatial-average responses exhibit near-exponential kinetics as expected, while concentration changes start at the ATPase end and propagate towards the mitochondrion, damped in time and space. (Mol Cell Biochem 174: 29–32, 1997)
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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