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  • 1
    ISSN: 1432-1041
    Keywords: Lansoprazole ; pharmacokinetics ; hepatic failure ; renal failure ; metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of lansoprazole (L) after a single oral dose of 30 mg was determined in 18 healthy volunteers, 17 renal failure patients and 24 hepatic failure patients; 8 hepatitis and 16 with compensated (CC) or uncompensated (UCC) cirrhosis. In renal failure, the absorption of L was unchanged, its half-life being similar to that in healthy subjects; a small change seen in mild renal failure patients (creatinine clearance between 40 and 60 ml/min) was attributed to the age of the patients. Urinary elimination, essentially as metabolites of lansoprazole, was decreased, in relation to the degree of renal impairment. In hepatitis patients, the AUC and t1/2 of L were doubled, without any change in Cmax. In cirrhotics tmax was prolonged, the AUC was increased (P〈0.001) and there was prolongation of t1/2 (6.1 h in CC and 7.2 h in UCC compared to 1.4 h in healthy subjects). These changes resulted from a decrease in the clearance of L. There was also an increase in its sulphone metabolite (Cmax, Rm) and a decrease in the hydroxylated metabolite (Cmax, Rm) in relation to the degree of liver disease, and reflecting a decrease in hydroxylation and biliary elimination. Thus, renal failure had no effect on the pharmacokinetics of L, but severe hepatic failure caused marked changes. A repeated dosing study would be necessary to evaluate the repercussions of the possible accumulation in cirrhotic patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Specific heat measurements on 2H-TaS2 single crystals have been carried out between 0.3 and 3 K using the ac calorimetry technique. An upturn in the normal-state data, obtained below 1 K in a 50-kG applied magnetic field, was observed to depend on the measuring frequency. It may be ascribed to a nuclear contribution with a relaxation rate directly proportional to absolute temperature. The basic parameters of the superconducting state have been determined, showing that the material is a very anisotropic, three-dimensional, type II superconductor. The broad transition observed in the heat capacity measurements cannot be analyzed in terms of fluctuations, but rather results from inhomogeneity effects.
    Type of Medium: Electronic Resource
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