Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract An approach to a transmembrane cation channel is described. It is based on the grafting of oxygen bearing side-chains on a macrocyclic polyether unit that constitutes the organizing core. The resulting species has a structure of overall bouquet shape. The synthesis of such a molecule .ℬ M 0 ,14a is described, together with that of its analogue bearing polymethylene side-chains ℬ M C ,14b. The physicochemical properties of these molecules indicate that they possess the features expected on the basis of their structure.
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