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  • 1955-1959  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    The use of cortisone and of long-acting ACTH to assess the biological activity of the somatotropic hormone (growth hormone) (1959)
    Springer
    Bulletin of experimental biology and medicine 47 (1959), S. 367-371 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A method of evaluating the biological effect of the somatotropic hormone is given. It is based on the ability of the growth hormone to stimulate the proliferation of the epiphyseal cartilage of rat's tibia. The inhibition of the proliferation of the epiphyseal cartilage is reached by the subcutaneous administration of cortisone for 4 days (1.5 mg once a day). Subsequent injections of the somatotropic hormone (75–100γ daily for 4 days) reestablish the width of the epiphyseal cartilage to 50% on the average. In the absence of cortisone it may be replaced by ACTH-zinc-phosphate (10 units subcutaneously once a day for 4 days). The usual ACTH cannot be employed for this purpose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00787792
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  • 2
    Electronic Resource
    Electronic Resource
    Photoperiodicity and the function of the hypophysis and the adrenal cortex (1958)
    Springer
    Bulletin of experimental biology and medicine 46 (1958), S. 999-1002 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ACTH content of the hypophysis of rats rises from a minimum in the morning to a maximum in the evening hours. These fluctuations are associated with the diurnal rhythm of light and darkness, and are abolished under conditions of continual light or darkness for 30 days. Rhythmic fluctuations of the ascorbic acid content of the adrenals are also found, with maximum values in the evening, and these are likewise abolished by maintenance under conditions of constant illumination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00787344
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    Paper (German National Licenses)
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