ISSN:
1617-4623
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Two loci,ma-l + andry +, necessary for xanthine dehydrogenase activity inDrosophila melanogaster have been studied for dosage effects utilizing deficiencies and duplications induced for this purpose. Comparisons of one, two and three doses ofma-l + in the female or one and two doses in the male indicate that there is no increase in specific enzyme activity with dose. On the other hand, comparisons of one, two and three doses ofry + in the male and female reveal an increase in enzyme activity that is roughly proportional to dose. Since dosage ofry + is limiting, whereas that ofma-l + is not, the final concentration of xanthine dehydrogenase is shown to depend on the number of doses ofry +. The implications of these findings with respect to the hypothesis of dosage compensation and to the mechanism of control of enzyme and protein concentration are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00888795
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