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  • 1970-1974  (20)
  • 1
    Electronic Resource
    Electronic Resource
    Potassium and proton movements in relation to the energy-linked transport of phosphate in liver mitochondria (1970)
    s.l. : American Chemical Society
    Biochemistry 9 (1970), S. 2092-2099 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00812a010
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of monazomycin on ion transport and oxidative phosphorylation in liver mitochondria (1971)
    s.l. : American Chemical Society
    Biochemistry 10 (1971), S. 1598-1603 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00785a015
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular behavior of the Carr-Price reaction (1972)
    s.l. : American Chemical Society
    Analytical chemistry 44 (1972), S. 570-573 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60311a045
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  • 4
    Electronic Resource
    Electronic Resource
    Model translocators for divalent and monovalent ion transport in phospholipid membranes (1974)
    Springer
    The journal of membrane biology 18 (1974), S. 187-199 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Adsorption of the antibiotic X-537A to lipid bilayers increases the membrane conductance to monovalent and divalent cations up to 104 times. From biionic potential measurements the following ionic selectivity sequences are derived: H+≫ Cs+〉Rb+, K+〉Na+〉Li+ for monovalent cations and Ba++〉Ca++〉Mn++〉Sr++≫〉Mg++ for divalent cations. The zero-current membrane potential in a gradient of H+ or Ca++ exhibits Nernst behavior. The membrane conductance is proportional to approximately the second power of the antibiotic concentration for both H+ and Ca++ conductances; it is linearly proportional to the H+ and Ca++ concentration in the aqueous phase at constant X-537A concentration. The H+-conductance exhibits a maximum at pH∼3.7, which may tentatively be ascribed to the salicylate moiety of the ionophore. When equimolar solutions of HCl and a divalent chloride salt are placed on opposite sides of an X-537A-doped membrane, a discrimination of H+ over the divalent cation is obtained. The dependence of the conductance on ionophore and ion concentration suggests that the permeant species for the H+ conductance is the dimer (HA2)−, (where A indicates the anionic form of the ionophore) and for the Ca++ conductance the dimer (CaHA2)+.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870111
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  • 5
    Electronic Resource
    Electronic Resource
    Model translocators for divalent and monovalent ion transport in phospholipid membranes (1974)
    Springer
    The journal of membrane biology 18 (1974), S. 201-218 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The antibiotic X-537A, already characterized as an ionophore for mono-, di- and trivalent cations across lipid membranes, inhibits ATP hydrolysis and glutamate oxidation stimulated in mitochondria by ion translocators such as monazomycin and beauvericin with the selectivity pattern: Cs+〉Rb+〉K+〉Na+〉Li+. The ionophore-mediated inhibition of both ATPase and respiration is fully reversed by concentration gradients of K+ and H+ imposed between intra-extra mitochondrial compartments. It is not reversed by modifying the concentrations of divalent or trivalent cations in the medium. These data as well as the substrate dependance of the respiratory inhibition indicate that X-537A inhibits energy transduction primarily by mediating the translocation of protons in exchange for K+ rather than by complexing divalent cations. Because of its ability to catalyze net proton transfer, concentrations of X-537A above 5×10−6 m uncouple the respiratory control of intact mitochondria. At concentrations below 10−6 m, the antibiotic releases the oligomycin-induced respiratory control of submitochondrial sonic particles with an alkali ion and proton-dependent selectivity as that shown to transport ions across lipid bilayers. It also stimulates a lanthanide-sensitive, ruthenium red-insensitive uptake of Ca2+ in submitochondrial sonic particles apparently occurring through an antiport type of electroneutral exchange diffusion of Ca2+ out/2H+ in.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870112
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  • 6
    Electronic Resource
    Electronic Resource
    Variability of the K+−Na+ discrimination of beauvericin in mitochondrial membranes (1972)
    Springer
    Journal of bioenergetics and biomembranes 3 (1972), S. 417-428 
    Details
    ISSN: 1573-6881
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract In intact mitochondria supplemented with succinate or β-hydroxybutyrate, the rates of oxygen consumption induced by beauvericin followed the ionic selectivity pattern: Na+〉Rb+, Cs+, K+, Li+. When the respiratory substrate is glutamate plus malate in the absence of phosphate, the selectivity pattern is: K+〉Rb+〉Cs+〉Li+〉Na+. When the media are supplemented with phosphate, the Na+/K+ discrimination of beauvericin is considerably modified with all the respiratory substrates, being K+〉Na+ with succinate and Na+〉K+ with glutamate plus malate, whereas no significant ionic selectivity differences were obtained with β-hydroxybutyrate. The respiratory control induced by oligomycin in submitochondrial particles is released by beauvericin only in the presence of a nigericin-like carboxylic antibiotic and an alkali metal cation, being far more effective in K+ than in Na+. This selectivity is maintained regardless of whether NADH or succinate is used as a respiratory substrate. Release of respiratory control can also be obtained with a combination of beauvericin and NH4Cl. This information indicates that the ionic selectivity pattern obtained with beauvericin in mitochondrial membranes is an intrinsic property of the antibiotic which, however, can be significantly modified by factors such as the nature of the translocatable substrate anion or other anionic species, as well as the possible operation of a Na+/H+ antiporter existent in the membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01516080
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  • 7
    Electronic Resource
    Electronic Resource
    Specific inhibition by macrocyclic polyethers of mitochondrial electron transport at site I (1972)
    Springer
    Journal of bioenergetics and biomembranes 3 (1972), S. 429-443 
    Details
    ISSN: 1573-6881
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The macrocyclic polyethers dibenzo-18-crown-6 (XXVIII) and dicyclohexyl-18-crown-6 (XXXI) inhibit the valinomycin-mediated K+ accumulation energized by glutamate, α-ketoglutarate, malate plus pyruvate or isocitrate but not that promoted by succinate, ascorbate plus TMPD or ATP. The polyethers inhibit the oxidation of the former group of substrates without preventing either the oxidation of succinate or ascorbate plus TMPD or the hydrolysis of ATP. The substrate oxidation inhibited by the macrocyclic polyethers is relieved in intact mitochondria by increasing the concentration of K+ in the medium. It is also completely reverted by supplementing the medium with valinomycin, Cs+ and phosphate, or else by the addition of vitamin K3. In submitochondrial sonic particles the macrocyclic polyethers inhibit the oxidation of NADH as well as the ATP-driven reversal of electron flow at the site I of the electron transport chain. They also block the oxidation of NADH in non-phosphorylating Keilin-Hartree particles as well as in Hatefi's NADH-coenzyme Q reductase. The polyethers do not inhibit electron transport in mitochondria from the yeast which lack the first coupling site. The inhibition of electron transport by the polyethers do not require of the addition of alkali metal cations such as K+ in intact mitochondria or other membrane preparations. It is established that the macrocyclic polyethers XXVIII and XXXI, already characterized as mobile carrier molecules for K+ in model lipid membranes, inhibit electron transport at site I of the electron transport chain from mitochondrial membranes. It is suggested that the ability of the polyethers to coordinate alkali metal cations in aqueous versus lipid environments, but not K+ transportper se, is related to their rotenone-like induced inhibition of electron flow in mitochondrial membranes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01516081
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  • 8
    Electronic Resource
    Electronic Resource
    Accumulation of calcium and phosphate stimulated by carboxylic antibiotics into mitochondria (1972)
    Springer
    Journal of bioenergetics and biomembranes 3 (1972), S. 361-375 
    Details
    ISSN: 1573-6881
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract Carboxylic ionophores such as nigericin, dianemycin, the monensins and compounds Lilly A 217 or X-537 A, stimulate an electron-transport dependent accumulation of Ca2+ and phosphate into mitochondria. Ion accumulation is stimulated under conditions of limited Ca2+ loading imposed by phosphate in the presence of β-hydroxybutyrate. Carboxylic ionophores do not affect divalent ion uptake when β-hydroxybutyrate is replaced for by succinate. They block Ca2+ and phosphate accumulation when energy is provided from the hydrolysis of ATP, or from the oxidation of glutamate, α-ketoglutarate, pyruvate or glutamate+malate. Nigericin-like antibiotics also transform the indefinite prolongation of state 3 respiration induced by Ca2+ and phosphate on β-hydroxybutyrate oxidation, into tightly coupled state 3 to 4 transitions. Evidence suggests that electrophoretic Ca2+ transport occurs in parallel with proton or K+ carriers. The anion movements associated to Ca2+ uptake are most probably driven by the existent ΔpH across the mitochondrial membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01516075
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  • 9
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    Variability of the K+?Na+ discrimination of beauvericin in mitochondrial membranes (1972)
    Springer
    Details
    Publication Date: 1972-09-01
    Print ISSN: 0145-479X
    Electronic ISSN: 1573-6881
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Springer
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  • 10
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    Accumulation of calcium and phosphate stimulated by carboxylic antibiotics into mitochondria (1972)
    Springer
    Details
    Publication Date: 1972-09-01
    Print ISSN: 0145-479X
    Electronic ISSN: 1573-6881
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Springer
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