ISSN:
1617-4623
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Expression of a late gene (R) of bacteriophage λ has been studied as a function of the state of five variables: the presence of the normal early rightwards promoter (pR), of an additional, immunity insensitive promoter (p′R), of immunity (im), of the N product (n) and of the Q product (q). Within the range of variables used, q appears as the necessary and sufficient condition for the expression of R (letting aside a minor component of late expression, which is regulated in an entirely distinct way: Dambly and Couturier, 1971). Expression of gene Q in turn requires positive control by the N product, in order to pass a transcriptional barrier which, in the absence of n, prevents the wave of transcription initiated at or near the immunity region from progressing beyond gene P. Immunity regulates negatively the expression of gene Q, both in a direct way (by preventing transcription from the promoter pR) and indirectly (by preventing expression of gene N by homoimmune phage). We have tried to analyze some of the logic complexities of the system and to provide the data and reasoning in a way which would facilitate criticism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00267155
Permalink
