ISSN:
0030-493X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
6-Methylthiopurines which bear a 9-NH- or a 9-NCH3-group (class A) form an [M - 1]-ion with much higher abundance than do the 1-, 3-, or 7-methyl derivatives (class B). The higher stability of the [M - 1]-ion in class A may be explained by ring closure to N-7.Methyl radicals are cleaved from N-, but not from S- or C-methyl groups, with the exception of the 7-methyl derivative, in which the S-CH3-group can also split off a methyl radical. The methylthio group may lose all of the following fragments: S, SH, SCH, SCH2 and SCH3. In the remaining purine skeleton, in general first the pyrimidine and subsequently the imidazole ring breaks down with elimination of HCN.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/oms.1210050305
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