ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis of a series of dodecapeptide ethyl esters containing L-leucine, L-ala-nine, glycine and L-lysine is described. These peptides are suitable carriers for the preparation of haptenic conjugates to be used in antigenicity studies. The strategy for preparing intermediary hexapeptides has been called a two-phase approach since the elongation of the peptide chain is carried out stepwise in a water-immiscible organic phase, whereas removal of side-products and excess reagent is effected by means of a suitably adapted aqueous phase. The method allows an efficient production of relatively large amounts of fully defined peptide antigens.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19720550403
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