ISSN:
1432-1041
Schlagwort(e):
Beta adrenergic receptor blockade
;
nitrates
;
placebo
;
coronary artery disease
;
exercise tests
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary 16 patients with coronary insufficiency on exertion were submitted to standardized work tests using a bicycle ergometer, after oral doses of placebo (PP), 5 mg sorbidnitrate + placebo (PS), 100 mg alprenolol (adrenergic beta-blocker) + placebo (AP) and 100 mg alprenolol + 5 mg sorbidnitrate (AS), allocated randomly in a double-blind trial. Total work done, work until pain, and work until the appearance of ST-depression increased significantly in the tests where an active drug had been used. The mean increase in total work was 44% for AS, 35% for AP and 26% for PS. AS was “best drug” in 11 of 16 patients, indicating a moderate synergism between its constituents. The greater heart rate increase in PS tests was completely blocked by alprenolol. Angina occurred at a significantly lower heart rate after both AP and AS. Half of the patients experienced some discomfort, usually headache, after PS or AS. No unusual side-effects were noted after alprenolol.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00619297
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