ISSN:
1432-1432
Keywords:
Aminoacylnucleotides
;
Amino acid esters
;
Peptides
;
Molecular evolution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary We have synthesized 2′(3′)-O-(glycyl)-adenosine-5′-(O-methylphos-phate), an analogue of the 3′-terminus of aminoacylated tRNA. A 0.4M solution of this compound maintained at pH 8.2, yields 5.5% of diglycine and 11.5% of diketopiperazine, in addition to the hydrolysis products glycine and adenosine-5′-(O-methylphosphate). Under the same conditions, glycine ethyl ester reacts much more slowly, but ultimately gives similar yields of diglycine and diketopiperazine. The aminolysis of 2′(3′)-O-(glycyl)-adenosine-5′-(O-methylphosphate) by free glycine is relatively inefficient, but serine reacts 20 times more rapidly and yields up to 50% of N-glycylserine. The prebiotic significance of these reactions is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01734480
Permalink