ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
Blood group P antigen and Pk antigen were recently identified as glycosphingolipid globoside, GalNAc(β, 1→3)Gal(α, 1→4)Gas(β, 1→4)Glc(β, 1→1)ceramide, and trihexosylceramide, Gal(α, 1→4)Gal(β, 1→4)Gld(β, 1→1)ceramide, respectively (Naiki & Marcus, 1974). The presence of antibodies to both antigens in the sera from rare p donors and antibodies to P antigen in the serum from a rare Pk donor were first demonstrated by the complement fixation test with the optimal antigen preparations containing each purified glycolipid, lecithin and cholesterol. In the serum from a p donor, most of antibody population of anti-P was IgM and was cross-reacted to Forssman glycolipid, GalNAc(α, 1→3)GalNAc(β, 1→3)Gal(α, 1→4)Gal(β, 1→4)Glc(β, 1→1) ceramide, but the rest of the anti-P antibodies and most of anti-Pk antibodies were IgG and had marked specificities for globoside and trihexosylceramide, respectively.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1978.tb00628.x
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