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  • 1975-1979  (2)
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  • 1
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    Hemodynamics, renal function, plasma renin, and aldosterone in man after 5 to 14 days of bedrest (1975)
    In:  Other Sources
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    Publication Date: 2019-06-27
    Description: Continuous bedrest for 5 to 14 days had no significant effect on resting heart rate, blood pressure, or cardiac output in six normal men. Head-up tilt induced greater tachycardia in 5 of 6 patients after bed rest than in the control period. Propranolol diminished both tachycardia and the incidence of hypotension and faintness in upright posture. Plasma volume fell, extracellular fluid volume increased, and plasma renin activity was significantly elevated following bedrest. Unusually large increases in plasma renin followed head-up tilt or administration of isoproterenol during bedrest and after resuming normal activity. During bedrest, plasma aldosterone was often increased in the early morning. It is concluded that after bedrest, upright posture evokes strong beta-adrenergic activity as well as exaggerated metabolic and circulatory responses which can be reduced or abolished by the beta-adrenergic blocker, propranolol.
    Keywords: AEROSPACE MEDICINE
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    NASA TECHNICAL REPORTS
  • 2
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    Effect of bedrest on circadian rhythms of plasma renin, aldosterone, and cortisol (1977)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: Previous studies of normal men after 5 d of bedrest showed that circulatory instability on head-up tilt or standing is preceded by increased plasma renin activity (PRA) at bedrest. In the present study, the circadian rhythms of PRA, aldosterone, and cortisol have been observed in five normal men on a constant diet. In ambulatory controls, PRA and aldosterone increased normally after standing. On the third morning of bedrest, PRA was higher than before, and at noon, PRA was higher than in standing controls. The nocturnal peaks of PRA resulting from episodic renin secretion during sleep were higher after bedrest. Plasma aldosterone was also increased by bedrest. The findings are compatible with the theory that intermittent beta-adrenergic nerve activity during sleep is increased after bedrest, but other factors, such as loss of body sodium and a lower plasma volume, may also be involved.
    Keywords: AEROSPACE MEDICINE
    Format: text
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    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
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