ISSN:
1432-1211
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Abstract Differential redistribution was used to investigate relationships between private specificity H-2.4 and public specificity H-2.28, in the product of aD region allele of theH-2 complex. Monospecific anti-H-2 antisera and fluorochrome conjugated antimouse Ig antibodies were used to induce redistribution of H-2 antigens on the surface of peripheral T lymphocytes fromH-2 a andH-2 d mice. Results showed that redistribution of specificity H-2.4 into patches and caps did not induce concomittant redistribution of specificity H-2.28, which remain diffusely scattered on the cell surface outside the caps of H-2.4. Redistribution of H-2.28 induced redistribution of H-2.4, which was no longer detectable outside the caps of H-2.28. These data indicate that (a) at least some of the H-2.28 sites are expressed on polypeptide chains independent from those carrying H-2.4 and (b) other H-2.28 sites may be linked to molecules carrying H-2.4. Since, onH-2 a cells, both specificities are products of the D region of theH-2 gene complex, our results suggest that there are at least two genes in theD region.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01572320
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