ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Poly(Lys(Cbz)-Ala-Glu(OBzl)) was prepared by the self-condensation of Lys(Cbz)-Ala-Glu(OBzl)-ONSu in dimethylformamide. After deprotection of the side chains, the product was subjected to Sephadex G-50 chromatography. The molecular weight of unfractionated and fractionated poly(Lys-Ala-Glu) was calculated from a calibrated Sephadex G-50 column, spectrophotometrically from Dnp-(Lys-Ala-Glu), equilibrium centrifugation, and viscosity measurements. Approximately 21% of the unfractionated material was polymeric with the remaining 79% being cyclic and monomeric material. Treatment of polymer hydrolysate with L-amino acid and D-amino acid oxidase indicated poly(Lys-Ala-Glu) to be optically pure. The apparent pKa's of the two ionizable groups were 4.1 and 9.7.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1977.360160711
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