ISSN:
1432-1041
Keywords:
Tolbutamide
;
diphenylhydantoin
;
drug interaction
;
disulfiram
;
clearance rate
;
serum level
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Diphenylhydantoin (DPH) and tolbutamide serum levels were studied in ten volunteers before and after 4 days of disulfiram treatment. The mean DPH half life incresed significantly from 11.0±1.2 h to 19.0±3.3 h, and the mean DPH metabolic clearance rate decreased significantly from 51.2±17.2 ml/min to 33.9±12.0 ml/min during medication. No significant changes in the half life or metabolic clearance rate of tolbutamide was observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00606562
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