Publication Date:
1978-02-17
Description:
Amantadine hydrochloride decreases the sensitivity of denervated mammalian muscle to iontophoretically applied acetylcholine. The drug depresses the amplitude of the end-plate current and reverses the slope of the relation between half-decay time and membrane potential suggesting that it alters the ionic conductance that is mediated by the acetylcholine receptor. Binding studies confirm that amantadine acts on the ion conductance modulator rather than the acetylcholine receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Albuquerque, E X -- Eldefrawi, A T -- Eldefrawi, M E -- Mansour, N A -- Tsai, M C -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):788-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622570" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylcholine/metabolism/*physiology
;
Amantadine/*pharmacology
;
Animals
;
Electric Conductivity
;
Electric Organ/drug effects/metabolism/physiology
;
Fishes
;
In Vitro Techniques
;
Membrane Potentials/drug effects
;
Motor Endplate/drug effects/metabolism/physiology
;
Muscle Denervation
;
Muscles/innervation/metabolism
;
*Neuromuscular Blocking Agents
;
Neuromuscular Junction/drug effects/metabolism/physiology
;
Rats
;
Receptors, Cholinergic/*drug effects
;
Receptors, Nicotinic/*drug effects/metabolism/physiology
;
Toxins, Biological/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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