ISSN:
1573-8221
Keywords:
rimantidin
;
phage and bacterial RNA polymerase
;
DNA polymerase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The action of rimantidin on reproduction of phages T3, T4, and λ was investigated. The maximal inhibitory action of the compound was observed between the first and sixth minute of infection with phage T3, but no such effect was observed on replication of phages T4 and λ. It is postulated on the basis of the results of incorporation of labeled precursors into phage DNA, RNA, and protein and the character of manifestation of the action of the compound on the phage yield that the inhibitory effect of rimantidin is evidently determined by its effect on bacterial and phage RNA polymerases, mainly on the latter.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00797137
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