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  • 1
    Electronic Resource
    Electronic Resource
    Effect of ethidium bromide on Ca2+ uptake by yeast (1978)
    Springer
    The journal of membrane biology 42 (1978), S. 199-213 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Ethidium bromide and other cationic dyes have been found to inhibit movalent cation uptake. This dye also produces in a K+-free medium an efflux of K+ which could be of the electrogenic type. The study of the effects of the same cationic dyes on Ca2+ uptake showed a large stimulation of the uptake rate of the divalent cation of more than tenfold. The analysis of the effects of one of the cationic dyes on Ca2+ uptake indicated that the efflux of K+ is of the electrogenic type and can drive the uptake of the divalent cation. Kinetic data on Ca2+ uptake indicate that, both under “normal” or under stimulated conditions, the divalent cation is taken up by the same transport system. The addition of ethidium bromide, besides, can stimulate the uptake of Mn2+ and14C-glycine and could be a good weapon to magnify and study some of the characteristics of ion transport systems in yeast.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870358
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction of ethidium bromide with the transport system for monovalent cations in yeast (1975)
    Springer
    The journal of membrane biology 22 (1975), S. 369-384 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Ethidium was found to be taken up by yeast cells in a process that, at certain concentrations has the main following characteristics: a) a substrate is required; b) it presents cooperative kinetics, withn, according to the Hill equation ≈3; c) ethidium can be concentrated more than 100-fold; d) the uptake is inhibited by Ca2+; e) the uptake of the dye is inhibited by monovalent cations with a selectivity pattern similar to that observed in their transport by yeast; f) ethidium inhibits the uptake of K+, and, at concentrations up to about 250 μm produces a competitive inhibition on the uptake of Rb+; and g) ethidium produces the same effects as K+ on respiration and the extrusion of H+. It is concluded that ethidium is taken up by yeast cells in a selective way by the same transport system normally employed for monovalent cation uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01868181
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  • 3
    Electronic Resource
    Electronic Resource
    Uptake and effects of several cationic dyes on yeast (1979)
    Springer
    The journal of membrane biology 47 (1979), S. 261-284 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Several cationic dyes were found to behave as inhibitors of K+ uptake in yeast. When added at high concentrations or in a K+-free medium, dyes can also produce and efflux of K+. The dyes are taken up by the cells in a process that, in different degrees, for several cations requires glucose and is inhibited to a higher degree by K+ than by Na+. The inhibition of cation uptake is of the competitive type with EB and close to this type with other dyes. Ca2+ inhibits the uptake and effects of dyes and in some cases also seems to change the inhibition kinetics on Rb+ uptake closer to a pure competitive type. According to preliminary experiments, the efflux of K+ seems to be of the electrogenic type, and not due to the disruption of the cells. The data indicate that, independently of the existence of other types of interaction (which do exist), dyes seem to interact with the system for monovalent cation uptake of yeast in different degrees of specificity and energy requirement. This interaction can be followed by fluorescence or metachromatic changes or reduction of the dyes as observed in the dual wavelength spectrophotometer and can be inhibited specifically by K+, but not by Na+.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01869081
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  • 4
    Electronic Resource
    Electronic Resource
    Evidence of crossing-over inhibition in rye anthers cultured with colchicine (1979)
    Springer
    Chromosoma 72 (1979), S. 151-155 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In order to investigate wheter colchicine affects crossing-over, rye anthers of an inbred line of rye forming bridges and fragments at anaphase I produced by erroneous chiasmata, and anthers of plants heterozygous for a conspicuous heterochromatin band, were cultured in a medium with colchicine. Anthers planted at zygotene did not show bridges at AI in the inbred line. In the heterozygotes no difference between associated chromatids in respect to the heterochromatin band, resulting from crossingover, were observed. In anthers planted at pachytene both bridges and chromosomes showing difference between associated chromatids were observed at a stage equivalent to AI with the same frequency as in anaphase I cells of untreated anthers. This demonstrates that crossing-over or a prerequisite to crossing-over is established at zygotene, and also that absence of chiasmate association at later stages is not due to precocious slipping off of chiasmata.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293231
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  • 5
    Electronic Resource
    Electronic Resource
    Colchicine induced asynapsis and c-meiosis in pollen mother cells of cultivated anthers of rye (1978)
    Springer
    Chromosoma 68 (1978), S. 261-267 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Rye anthers were cultured in medium with colchicine for periods of 12–24 h. Unaffected PMCs showed normal meiotic pairing in the same anthers in which other PMCs showed several degrees of asynapsis (or desynapsis), c-meiosis or anaphase irregularities. Pairing was affected only in cells which were at mid zygotene at the time of treatment initiation. Chiasma terminalization and release was possible in the absence of a functional spindle. Possibly, spindle function is more sensitive to colchicine than pairing. Variation within anthers can be adscribed to gradients in stage and development. The possibility of differences in penetration of colchicine must be recognized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335420
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  • 6
    Electronic Resource
    Electronic Resource
    Kinetk des Teilchenwachstums. II. Schwefelsäure-Aerosol durch Photooxidation von SO2 in feutchen Sauerstoff Stickstoffe-Gemischen (1977)
    Springer
    Colloid & polymer science 255 (1977), S. 928-929 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01617131
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  • 7
    Electronic Resource
    Electronic Resource
    Unusually high oxygen effect in cortisone resistant thymocytes (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 605-606 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Thymic lymphocytes were assayed for their radiobiological oxygen effect. We found a large OER (12±0.8) for the cortisone-resistant fraction in contrast to a normal OER (3.5±0.8) for the cortisone-sensitive ones. Possible correlation of this difference with known characteristics in membrane related parameters are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946525
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of captivity on glucose tolerance in dogs (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 876-877 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Captivity decreased tolerance to glucose and increased blood serotonin levels in 6 normal dogs investigated. Return to freedom brought normalization in the glucose tolerance test and reverted blood serotonin to control levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955123
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  • 9
    Electronic Resource
    Electronic Resource
    The effects of dopaminergic blocking agents on the glucose tolerance test in 6 humans and 6 dogs (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 886-887 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Pre-treatment with low doses of sulpiride, an atypical dopaminergic blocking agent, but not haloperidol, a classical dopaminergic blocking agent, decreased tolerance to glucose and increased blood serotonin levels in 6 normal humans and 6 normal dogs investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955130
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  • 10
    Electronic Resource
    Electronic Resource
    Stochastic theory for classical and quantum mechanical systems (1975)
    Springer
    Foundations of physics 5 (1975), S. 355-370 
    Details
    ISSN: 1572-9516
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We formulate from first principles a theory of stochastic processes in configuration space. The fundamental equations of the theory are an equation of motion which generalizes Newton's second law and an equation which expresses the condition of conservation of matter. Two types of stochastic motion are possible, both described by the same general equations, but leading in one case to classical Brownian motion behavior and in the other to quantum mechanical behavior. The Schrödinger equation, which is derived here with no further assumption, is thus shown to describe a specific stochastic process. It is explicitly shown that only in the quantum mechanical process does the superposition of probability amplitudes give rise to interference phenomena; moreover, the presence of dissipative forces in the Brownian motion equations invalidates the superposition principle. At no point are any special assumptions made concerning the physical nature of the underlying stochastic medium, although some suggestions are discussed in the last section.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00717450
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