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  • ASTROPHYSICS  (418)
  • Life and Medical Sciences  (224)
  • Humans
  • Lunar and Planetary Science and Exploration
  • 1975-1979  (715)
  • 1950-1954  (54)
  • 1
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    Genetically determined sex-reversal in 46,XY humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similiar to those of 45,X women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉German, J -- Simpson, J L -- Chaganti, R S -- Summitt, R L -- Reid, L B -- Merkatz, I R -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):53-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567843" target="_blank"〉PubMed〈/a〉
    Keywords: Disorders of Sex Development/embryology/*genetics ; Female ; Humans ; Karyotyping ; Male ; Ovary/embryology ; Pedigree ; Sex Chromosome Aberrations/embryology ; Testis/embryology ; Turner Syndrome/embryology/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Premature senescence in cultured skin fibroblasts from subjects with cystic fibrosis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-23
    Description: Cultured skin fibroblasts from subjects with cystic fibrosis exhibited normal population doubling times in early passages. After about 13 cumulative population doublings, cystic fibrosis lines doubled more slowly than controls and ceased doubling after about 19 weekly passages. Control lines continued doubling for 27 passages. The premature senescence noted in cells from subjects with cystic fibrosis reconciles controversial observations of cell doubling reported in the literature. Data presented here demonstrate that experiments with cystic fibrosis cells in late passage may generate misleading results since differences from control lines may be ascribed to generalized senile changes rather than to specific results of the cystic fibrosis genotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, B L -- Lam, L F -- Fast, L H -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1251-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424752" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aging ; Cell Division ; *Cell Survival ; Cells, Cultured ; Child ; Cystic Fibrosis/*pathology ; DNA/biosynthesis ; Female ; Humans ; Male ; Skin/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The radiation history of material returned by the Soviet automatic stations Luna 16 and Luna 20, according to track studies (1977)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: Fission tracks formed by the vH (very heavy) nuclei group of solar and galactic cosmic rays have been studied in silicate minerals of the lunar regolith returned by the Luna 16 and Luna 20 unmanned spacecraft. It is shown that the material in the Luna 16 core sample, from a typical mare region of the lunar surface, has undergone stronger irradiation by cosmic rays than material returned a highland region by Luna 20. A low-irradiation component (about 10 percent of the total number of crystals) has been found in the Luna 20 core sample materials, which can possibly be attributed to material added to the main bulk of the regolith in the formation of the crater Apollonius C. From the track density distribution of crystals, as a function of depth in the regolith core sample, it follows that the process of formation of the upper layer of the regolith, both for the lunar mare and for the highland region, includes sequential layering of finely crushed crystalline matter and subsequent mixing of it by micrometeorite bombardment. A portion of the crystals with a very high track density may be a component added to the lunar surface from outer space.
    Keywords: ASTROPHYSICS
    Type: NASA, Washington The Soviet-Am. Conf. on Cosmochem. of the Moon and Planets, Pt. 2; p 745-754
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Investigation of the composition of the Luna 16 lunar sample (1977)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: The concentrations of aluminum, manganese, sodium, chromium, iron, cobalt, and 12 rare earth elements were determined by neutron activation analysis using slow neutrons. Oxygen and silicon were determined using a fast neutron generator. Mossbauer spectroscopy was used to investigate iron compounds in Luna 16 regolith samples from the upper part of the core.
    Keywords: ASTROPHYSICS
    Type: NASA, Washington The Soviet-Am. Conf. on Cosmochem. of the Moon and Planets, pt. 1; p 277-280
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    NASA TECHNICAL REPORTS
  • 5
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    Stellar model chromospheres. XI - A survey of Ca II lambda 8542 line profiles in late-type stars of differing chromospheric activity (1979)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Keywords: ASTROPHYSICS
    Type: PB80-144215 , Astrophysical Journal Supplement Series; 41; Nov. 197
    Format: text
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    NASA TECHNICAL REPORTS
  • 6
    Electronic Resource
    Electronic Resource
    Tissue microenvironment and the genetic control of hair pigment patterns in mice (1979)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 1 (1979), S. 167-179 
    Details
    ISSN: 0192-253X
    Keywords: agouti locus ; hair pigment patterns ; melanocyte metabolism ; tissue microenvironment ; eumelanin ; phaeomelanin ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: This study was conducted to assess microenvironmental variability within integumental tissue of genetically identical mice with respect to a specific cellular response: cyclic synthesis of yellow and black pigment by hair bulb melanocytes. Crosses were performed within and between inbred strains of mice that were isogenic with the exception of a single gene substitution at the agouti locus. Agouti locus genes included the Avy, Aw, A, atd, at, ax, am, and a alleles. The pigment patterns of dorsal, flank, and ventral hairs of the first and third hair generations and of hairs growing in special integumentary areas such as the pinna, tail, and hind foot were studied. It was found that the amount of yellow pigment synthesized by hair bulb melanocytes within genetically identical mice is both agedependent and conditioned by the integumentary environment. Furthermore, the special integumentary regions produce hairs with a variety of pigment patterns in which the distribution and relative amounts of black and yellow pigments do not necessarily conform to dominance relationships expected among agouti locus alleles as judged by their effects on the pigmentation of the dorsal pelage. We conclude that within genetically uniform integumental tissues, microenvironmental differences occur and are reflected as alterations in the metabolic pattern of differentiated cells.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020010205
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  • 7
    Electronic Resource
    Electronic Resource
    Mutations specific to spore maturation in the asexual fruiting body of dicytostelium discoideum (1979)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 1 (1979), S. 355-362 
    Details
    ISSN: 0192-253X
    Keywords: Dictyostelium discoideum ; spore maturation ; spore specific mutations ; cell patterning ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Three mutations affecting spore maturation in the asexual fruiting body of Dictyostelium discoideum are assigned to a new locus, sprJ, on linkage group IV. Strains carrying mutations at the sprJ locus do not form mature spores, yet the cell patterning (spore, stalk and disc cell ratios) is apparently normal. These mutations will be useful to delineate branch points between the cell patterning and spore maturation pathways. There are some unusual features of the sprJ-containing mutants. In particular each of the parent strains of the three mutants has incomplete spore maturation as determined by colony-forming ability after heat shocking at 45°C. A mutation allowing growth in the presence of benlate (600 μg/ml), benA351, is mapped to linkage group I.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020010408
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  • 8
    Electronic Resource
    Electronic Resource
    The normal membrane resting potential of mammalian skeletal muscle measured in vivo (1953)
    Philadelphia : Wiley-Blackwell
    Journal of Cellular and Comparative Physiology 42 (1953), S. 343-357 
    Details
    ISSN: 0095-9898
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1030420303
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  • 9
    Electronic Resource
    Electronic Resource
    The electrical activity of single muscle fibers (1950)
    Philadelphia : Wiley-Blackwell
    Journal of Cellular and Comparative Physiology 35 (1950), S. 39-73 
    Details
    ISSN: 0095-9898
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1030350105
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  • 10
    Electronic Resource
    Electronic Resource
    Salivary gland development in the blowfly, Calliphora erythrocephala (1976)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 149 (1976), S. 459-482 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The salivary gland of adult Calliphora erythrocephala is a tubular structure composed of secretory, reabsorptive, and duct regions. Development of these structures has been followed during the six days of larval and ten days of pupal growth. Two small groups of imaginal cells located at the junction between larval gland and duct give rise to the adult gland. These presumptive adult cells divide during all larval stages and appear to be functional components of the larval gland. Shortly after pupation, the larval gland breaks down and the imaginal cells proliferate rapidly, forming sequentially the duct, reabsorptive and secretory regions. Proliferating regions of the developing gland are frequently encrusted with haemocytes. As it elongates the gland establishes intimate contacts first with the basement membrane of the degenerating larval gland, later with an epithelial layer surrounding the main dorsal tracheal trunks, and then with the gut. Cell division continues until about five days after pupation, bu t the gland is unable to secrete fluid in response to 5-hydroxytryptamine stimulation until two hours after the adult fly emerges. The Golgi complex appears to be involved in forming the highly folded membranes of the canaliculi in the secretory region.Presumptive adult salivary gland cells appear to increase in number logarithmically from the time of hatching of the larva until five days after pupation. This contrasts with the development of classical imaginal discs, in which cell division ceases prior to pupation.
    Additional Material: 35 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051490403
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