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  • 1
    ISSN: 1432-0983
    Keywords: Key words Transcriptional regulation ; Phospholipid biosynthesis ; Saccharomyces cerevisiae ; INO2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Expression of structural genes of phospholipid biosynthesis in yeast is mediated by the inositol/choline-responsive element (ICRE). ICRE-dependent gene activation, requiring the regulatory genes INO2 and INO4, is repressed in the presence of the phospholipid precursors inositol and choline. INO2 and, to a less extent, INO4 are positively autoregulated by functional ICRE sequences in the respective upstream regions. However, an INO2 allele devoid of its ICRE functionally complemented an ino2 mutation and completely restored inositol/choline regulation of Ino2p-dependent reporter genes. Low-level expression of INO2 and INO4 genes, each under control of the heterologous MET25 promoter, did not alter the regulatory pattern of target genes. Thus, upstream regions of INO2 and INO4 are not crucial for transcriptional control of ICRE-dependent genes by inositol and choline. Interestingly, over-expression of INO2, but not of INO4, counteracted repression by phospholipid precursors. Possibly, a functional antagonism between INO2 and a negative regulator is the key event responsible for repression or de-repression.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 27 (1976), S. 560-568 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Precipitation and corrosion behaviour of unstabilized and stabilized 18 10 CrNi steels after short term sensibilizing annealingThe authors have studied the precipitation behaviour of the steels X5 CrNi 18 9, X10CrNiTi 18 9 and X 10CrNiNb 18 9 after solution and sensibilization annealing, and the intercrystalline corrosion behaviour in the Straußtest. On the basis of the results obtained it was possible to determine the and carbonitrides and to define the grain segregation ranges. In the case of the unstabilized materials the behaviour is a function of the formation of chromium depleted zones. However, it is not absolute value of the depletion at the carbid/austenite interphase which controls corrosion, but the depletion in an adjacent zone of measurable thickness. Beyond that the Huey test allows the corrosion susceptibility to be determined in those regions where no continuous chromium depleted zone exists. In the case of stabilized steels the corrosion behaviour depends in addition from carbonitride precipitation, since these compounds are heavily attacked by the boiling nitride acid.
    Notes: Die Verfasser untersuchten das Ausscheidungsverhalten der Stähle X 5 CrNi 18 9, X 10CrNiTi 18 9 und X 10CrNiNb 18 9 nach Lösungs- und Sensibilisierungsglühen sowie das Verhalten gegen interkristalline Korrosion im Strauß-Versuch. Aufgrund der Ergebnisse konnte die Art der Ausscheidungen bestimmt werden (Karbid M23C6 und Karbonitride) und auch die Kornzerfallsbereiche konnten definiert werden. Im Falle des nichtstabilisierten Materials ist das Verhalten abhängig von der Bildung von chromveramten Zonen; dabei ist jedoch nicht die absolute Höhe der Verarmung an der Grenzfläche Kabid/Austenit ausschlaggebend, sondern vielmehr die Verarmung in einer Zone meßbarer Dicke. Im Huey-Versuch läßt sich außerdem die Korrosionsanfälligkeit in den Zonen ermitteln, wo keine zusammenhängende Chromverarmungszone vorliegt. Im Falle der stabilisierten Stähle ist das Korrosionsverhalten außerdem abhängig von der Karbonitridausscheidung, da diese Ausscheidungen von der siedenden Salpetersäure stark angegriffen werden.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1617-4623
    Keywords: Prolidase ; Metalloprotease ; Lactobacillus delbrueckii subsp. lactis ; Nucleotide sequence analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract From a genomic library of Lactobacillus delbrueckii subsp. lactis (DSM7290) DNA, in the low-copy-number vector pLG339, a recombinant clone was selected, which complemented a mutation in the prolidase gene (pepQ) of Escherichia coli UK173. Nucleotide sequence analysis revealed an open reading frame of 1104 nucleotides corresponding to a protein of 368 amino acids with a calculated pI of 4.64 and a molecular mass of 41087 Da. The start site of pepQ transcription was determined by primer extension analysis with mRNA prepared from L. delbrueckii. Based on homology of the gene product to various peptidases and on the substrate specificity determined, the peptidase was designated PepQ. The influence of various protease inhibitors and cations on peptidase activity indicated that PepQ is a metalloprotease. The absence of a membrane-spanning domain and a signal peptide sequence argues for a cytoplasmic localization of the enzyme.
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  • 4
    ISSN: 0935-9648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 4 Ill.
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 14 (1998), S. 1041-1050 
    ISSN: 0749-503X
    Keywords: Saccharomyces cerevisiae ; STRE ; stress response ; genomics ; bioinformatics ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Stress response elements (STREs, core consensus AG4 or C4T) have been demonstrated previously to occur in the upstream region of a number of genes responsive to induction by a variety of stress signals. This stress response is mediated by the homologous transcription factors Msn2p and Msn4p, which bind specifically to STREs. Double mutants (msn2 msn4) deficient in these transcription factors have been shown to be hypersensitive to severe stress conditions. To obtain a more representative overview of the set of yeast genes controlled via this regulon, a computer search of the Saccharomyces cerevisiae genome was carried out for genes, which, similar to most known STRE-controlled genes, exhibit at least two STREs in their upstream region. In addition to the great majority of genes previously known to be controlled via STREs, 69 open reading-frames were detected. Expression patterns of a set of these were examined by grid filter hybridization, and 14 genes were examined by Northern analysis. Comparison of the expression patterns of these genes demonstrates that they are all STRE-controlled although their detailed expression patterns differ considerably. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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