Publication Date:
1983-07-01
Description:
In man and animals iodothyronines are metabolized by deiodination and conjugation with glucuronic acid or sulfate. Until now these processes have been regarded as independent reactions. However, in the present study a close interaction of these pathways was observed in the hepatic metabolism of 3,3'-diiodothyronine and 3,3',5-triiodothyronine. Studies with rat hepatocytes and liver microsomes indicated that sulfation of the phenolic hydroxyl group facilitates the deiodination of these compounds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Otten, M H -- Mol, J A -- Visser, T J -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):81-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857270" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Diiodothyronines/metabolism
;
Liver/cytology/drug effects/*metabolism
;
Microsomes, Liver/metabolism
;
Propylthiouracil/pharmacology
;
Rats
;
Sulfates/metabolism
;
Thyroid Hormones/*metabolism
;
Triiodothyronine/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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