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A cooling system for prostaglandin infusions (1981)

Krausz, Michael M. ; Justice, Richard E. ; Utsunomiya, Takayoshi ; [et al.]

Springer

Annals of biomedical engineering 9 (1981), S. 257-262

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ISSN: 1573-9686

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine , Technology

Notes: Abstract A simple system has been developed-for the prolonged infusion of an iced solution of prostacyclin (PGI2). In a 24 h period at pH 10, there is a theoretical loss in activity of 6%, while a 5 h infusion leads to a 2% reduction in activity. The stability of the cooling system was demonstrated in six dog experiments where mean arterial pressure (MAP) was reduced to 58±3.8 Torr (x±SEM) over a 5 h period of infusing 500 ng/kg/min. In a saline medium, at 3°C, a 5 h PGI2 infusion led to a stable reduction in MAP, whereas, at a temperature of 24°C, a 70 loss of infusate activity was noted.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02363459

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