ISSN:
1573-904X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract N-(p-Chlorobenzoyl)-sulfamate was observed to produce potent hypolipidemic activity in rodents at 10 to 60 mg/kg/day. Liver phosphatidate phosphohydrolase and sn-glycerol-3-phosphate acyl transferase activities were suppressed by the agent in vitro and in vivo, and ATP dependent citrate lyase and acetyl CoA carboxylase activities were reduced in vivo. N-(p-Chlorobenzoyl)-sulfamate reduced cholesterol, neutral lipids, and triglycerides in the liver and increased excretion of cholesterol and neutral lipids in the bile and feces. Drug treatment reduced the neutral lipid and triglyceride content of serum chylomicrons, VLDL and LDL, and cholesterol content was reduced in the chylomicron and HDL fractions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1016326625380
Permalink