Publication Date:
1983-08-05
Description:
Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and is associated with three human malignancies. Acyclovir [9-(2-hydroxyethoxymethyl)guanine], the first clinically useful drug effective against replication of EBV, is without effect against latent or persistent EBV infection. Three nucleoside analogs, E-5-(2-bromovinyl)-2'-deoxyuridine, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine, and 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil are potent inhibitors of EBV replication in vitro. Moreover, in contrast to the reversibility of viral inhibition by Acyclovir, these three drugs have prolonged effects in suppressing viral replication even after the drugs are removed from persistently infected cell cultures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, J C -- Smith, M C -- Cheng, Y C -- Pagano, J S -- 5-PO1-CA-19014/CA/NCI NIH HHS/ -- CA-16086/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):578-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306771" target="_blank"〉PubMed〈/a〉
Keywords:
Acyclovir/*pharmacology
;
*Antiviral Agents
;
Arabinofuranosyluracil/*analogs & derivatives/pharmacology
;
Bromodeoxyuridine/*analogs & derivatives/pharmacology
;
Cytarabine/*analogs & derivatives/pharmacology
;
DNA Replication/*drug effects
;
Herpesvirus 4, Human/*drug effects
;
Uridine/*analogs & derivatives
;
Virus Replication/*drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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