Publication Date:
1982-05-28
Description:
Oxytocin has insulin-like activity in that it stimulates lipogenesis and increases pyruvate dehydrogenase activity. However, in adipocytes from homozygous Brattleboro rats oxytocin is incapable of stimulating lipogenesis or pyruvate dehydrogenase activity, although insulin stimulation of both processes is normal and the antilipolytic activity of oxytocin is normal. Thus, the Brattleboro rat provides a new genetic model for the study of oxytocin action, wherein recognition of the chemical mediator is partially defective.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hanif, K -- Lederis, K -- Hollenberg, M D -- Goren, H J -- New York, N.Y. -- Science. 1982 May 28;216(4549):1010-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079746" target="_blank"〉PubMed〈/a〉
Keywords:
Adipose Tissue/*enzymology
;
Animals
;
Enzyme Activation/drug effects
;
Lipid Mobilization/drug effects
;
Oxytocin/*pharmacology
;
Pyruvate Dehydrogenase Complex/*metabolism
;
Rats
;
Rats, Mutant Strains/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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