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  • 1
    Electronic Resource
    Electronic Resource
    Application of the ‘dual sorption’ model to drug transport through skin (1980)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 20 (1980), S. 36-39 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The dual sorption theory has been extended to the transport of drug molecules through human skin in vitro. By assuming that sorption of drug molecules occurs by both dissolution and binding of drug to immobile sites in the skin, the experimental sorption isotherm can be predicted, and the disparity between steady state and time lag diffusivities can be reconciled. Furthermore, the dual sorption model has been used to develop techniques for controlling these sorption transport processes in order to rapidly achieve predictable transdermal drug delivery in vivo.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760200107
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  • 2
    Electronic Resource
    Electronic Resource
    Mass transfer between a turbulent fluid and a solid boundary: Linear theory (1982)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 28 (1982), S. 988-993 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A linear form of the mass balance equation is used to determine how turbulent transport of mass to a solid wall is related to the fluctuating velocity field. It is found that at high Schmidt numbers the Reynolds transport is controlled by fluctuations of much lower frequency than the most energetic velocity fluctuations. The characteristic of the velocity field that emerges as being most important is the small frequency limiting value of the spectral function of the velocity fluctuations normal to the wall. However, the linear theory that is explored does not predict the correct dependency of the average and the mean-squared deviation of the mass transfer coefficient on Schmidt number. A nonlinear analysis must be performed to examine fully the mechanism of turbulent mass transfer to a solid surface.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690280614
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  • 3
    Electronic Resource
    Electronic Resource
    Turbulent velocity fluctuations that control mass transfer to a solid boundary (1983)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 29 (1983), S. 215-221 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The relation between the velocity and concentration fields for a fully developed turbulent flow which transfers mass to a pipe wall at large Schmidt numbers has been studied. Measurements of the fluctuations of the concentration gradient and the velocity gradient were obtained simultaneously at multiple locations on the wall. Spatial scales were calculated for the low frequency velocity fluctuations by passing the measured signals through low-pass filters. These scales are the same size as the scales of the concentration fluctuations. This result provides additional support for the notion that mass transfer to a boundary at high Schmidt numbers in controlled by low frequency velocity fluctuations which contain only a small fraction of the total turbulent energy.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690290207
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  • 4
    Electronic Resource
    Electronic Resource
    Mechanism of turbulent mass transfer at a solid boundary (1983)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 29 (1983), S. 221-229 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Mass transfer between a turbulent fluid and a solid boundary is considered for the case of large Schmidt numbers. The variation of the mass transfer coefficient with time, K(t), is calculated by solving the mass balance equation using a random velocity input. An interpretation of the mass transfer process which is radically different from that given by classical approaches is obtained.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690290208
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  • 5
    Electronic Resource
    Electronic Resource
    Folate utilization in friend erythroleukemia cells (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 114 (1983), S. 252-256 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: In order to study the generation, factors controlling endogenous folate pools, and their functional importance, Friend erythroleukemia cells were grown in media containing 100; 1,000; and 10,000 ng/ml of tritiated pteroylglutamic acid (3H)PteGIu1 and then studied in unlabeled media with varying amounts of PteGlu1. The intracellular folate pool was directly proportional to the PteGlu1 in which the cells were incubated. At equilibrium, greater than 95% of the labeled intracellular folate pool chromatographed as polyglutamyl folate, regardless of the exogenous folate concentration. The functional importance of the intracellular folate pool was studied by varying the endogenous pool and the exogenous (media) supply. The ability of the cells to replicate in the absence of exogenous folate was directly proportional to the intracellular polyglutamyl folate pool. The maximal rate of replication, however, required exogenous PteGlu1 in addition. The cell doubling time was the most important determinant of intracellular folate turnover; changes in the intracellular pool size and the extracellular folate concentration had no effect on the turnover time. In a rapidly proliferating tissue, the onset of functional folate deficiency will be determined by dilution of intracellular polyglutamates among progeny until a critical level is reached.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041140216
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of hormones and amino acid depletion on the kinetic parameters of amino acid uptake in monolayer cultures of rat hepatocytes (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 112 (1982), S. 67-75 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Uptake of 2-aminoisobutyric acid (AIB) at concentrations of 0.1 mM to 30 mM was examined in sodium-containing and sodium-free media in hepatocytes pretreated without hormones (control), with hormones, or with amino acid depletion. Results show that 1-minute but not 4-minute rates can be taken as initial rates for the total or sodium-dependent transport of AIB. The data for the 1-minute sodium-dependent transport of AIB were analyzed by a comptuer program and also by Eadie-Hofstee and Lineweaver-Burk plots, and a single saturable system was found. In the control cultures, the saturable system had a Km of 1-2 mM AIB and a Vmax of 1.2 nmoles AIB/mg protein/minute. There was an increase in the Vmax of two to three-fold after pretreating the cultures with insulin or amino acid depletion, three to four-fold with glucagon, and six to seven fold with glucagon + dexamethasone.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041120111
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  • 7
    Electronic Resource
    Electronic Resource
    Factors influencing survival and growth of mammalian cells exposed to hypothermia. I. Effects of temperature and membrane lipid perturbers (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 115 (1983), S. 179-185 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The Arrhenius plot of the rate of V79 Chinese hamster cell inactivation due to hypothermia has a “break” around 7-10°C with optimum storage temperature for unprotected cells being about 10°C. Addition of the membrane lipid perturber, butylated hydroxytoluene, improves survival of cells when compared to controls at temperatures below this break but not above. Arrhenius plots of growth rates of the cells show breaks at 30 and 40°C. Measurements of membrane fluidity by electron spin resonance or membrane polarization anisotropy by fluorescence spectrophotometry techniques as a function of temperature in these cells also reveal “breaks” centered around 8 and 30°C. Hence, the changes in the rate of cell inactivation and growth as a function of temperature may be related to membrane lipid phase changes.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041150212
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  • 8
    Electronic Resource
    Electronic Resource
    Flow behavior of PVC in hot-die-face pelletizing: Die hole pattern optimization (1980)
    Brookfield, Conn. : Wiley-Blackwell
    Journal of Vinyl and Additive Technology 2 (1980), S. 188-194 
    Details
    ISSN: 0193-7197
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Die hole pattern optimization can minimize the pressure loss across the die plate for a given set of products, while maintaining sufficient steel strength. Data will be presented from a high-pressure capillary rheometer to establish flow behavior and investigate the effects of die geometry on flow resistance. The influence of formulation parameters, degree of gelation and shear gradient will be considered. Finally a model will be developed for the optimization of the die hole pattern. Using this procedure, it will be possible to establish the data needed for optimal die hole pattern design by calculation and graphic presentation.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/vnl.730020311
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  • 9
    Electronic Resource
    Electronic Resource
    Liquid/solid separation. Cake filters in batch filtration. An authoritative discussion of the advantages and disadvantages of the filter press and the pressure-leaf filter (1983)
    New York, NY : Wiley-Blackwell
    Plant/Operations Progress 2 (1983), S. 216-221 
    Details
    ISSN: 0278-4513
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prsb.720020406
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