Publication Date:
1983-08-12
Description:
Two regions in the immunoglobulin heavy chain locus were tested for their ability to enhance transcription of the SV40 early promoter. A portion of the intervening sequence between the heavy chain joining region (Jh) and the constant region of the mu chain (Cmu) can enhance transcription when it is cloned either 5' or 3' to the SV40 early promoter. The region between C alpha and the alpha switch site, which occurs 5' to the translocated c-myc oncogene in many murine plasmacytomas, does not show transcriptional enhancer activity in this assay.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercola, M -- Wang, X F -- Olsen, J -- Calame, K -- GM 29361/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):663-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306772" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cloning, Molecular
;
*Gene Expression Regulation
;
Genetic Vectors
;
Immunoglobulin Heavy Chains/*genetics
;
Mice
;
Operon
;
Simian virus 40/genetics
;
*Transcription, Genetic
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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