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  • Analytical Chemistry and Spectroscopy  (16)
  • Wiley-Blackwell  (16)
  • 2005-2009
  • 1990-1994  (8)
  • 1980-1984  (8)
  • 1
    Electronic Resource
    Electronic Resource
    Computer modelling of fragmentation processes in radio frequency multipole collision cells (1990)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 4 (1990), S. 186-197 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: To date, methods for calculating the trajectories of ions in radio frequency (RF) multipole fields have involved solving, analytically or numerically, the appropriate equations of motion. Another method is presented here whereby a non-ideal distribution of field may be modelled and the position of an ion can be tracked, as it traverses the multipole. The validity of the calculations is discussed and some of the properties of collision cells are explained. Fragmentation processes within the cell are modelled showing that the focusing properties within the cell have a striking effect on parent- and daughter-ion transmission.
    Additional Material: 24 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290040605
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  • 2
    Electronic Resource
    Electronic Resource
    Mass spectrometry of 2-substituted-4-arylthiazoles: II-identification of microsomal nitroreduction product by mass spectrometry (1982)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 9 (1982), S. 376-380 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Electron impact fragmentation of 2-methyl-4-(4-nitropenyl)-thiazole and 2-amino-4-(4-nitrophenyl)-thiazoles were studied. Prominent fragment ions result from: (1) elimination of an NO2 radical and of a neutral NO molecule; (2) 1,2 cleavage of the thiazole ring in both compounds to give a phenoxythiirene ion; and (3) subsequent cleavage of this phenoxythiirene ion to give the common ions [C7H5] and [C5H3]. An anaerobic microsomal nitroreduction product of 2-methyl-4-(4-nitrophenyl) thiazole was isolated and its structure was determined by electron impact, chemical ionization and high resolution mass spectrometry to be 2-methyl-4-(4-aminophenyl)-thiazole.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200090904
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  • 3
    Electronic Resource
    Electronic Resource
    Chemical ionization mass spectra of derivatized 1-benzyltetrahydroisoquinoline alkaloids (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 63-67 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A study of the chemical ionization mass spectral characteristics of a series of derivatized 1-benzyltetrahy-droisoquinoline alkaloids is presented. Tetrahydropapaveroline and some related benzyltetrahydroisoquinolines were converted to their corresponding O-trimethylsilyl of N-trifluoroacetyl-O-trimethylsilyl derivatives prior to analysis by combined gas chromatographic methane chemical ionization mass spectrometry. The chemical ionization mass spectra of the derivatized alkaloids are compared to the electron impact mass spectra of the N-trifluoroacetyl-O-trimethylsilyl derivative of tetrahydropapaveroline, a representative benzyltetrahydroisoquinoline alkaloid. The effects of the nitrogen substituent and ion source pressure on the relative abundance of significant ions in the chemical ionization mass spectra of these alkaloids are also described.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200110204
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  • 4
    Electronic Resource
    Electronic Resource
    Mass spectrometry of 2-substituted-4-arylthiazoles. 3 - identification of microsomal nitroreduction products by mass spectrometry (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 149-154 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electron impact mass spectra of the chemical carcinogens 4-(4-aminophenyl)-2-methylaminothiazole, 4-(4-aminophenyl)-2-methylaminothiazole, and 4-(4-aminophenyl)-2-aminothiazole were studied. The 3-(4-aminophenyl)-2-substituted thiazoles were isolated from the anaerobic microsomal reduction of their respective 4-nitrophenyl analogues. Microsomes prepared from rat and rabbit kidney tissues were used. The identity of the reduction products were established by chemical synthesis and mass spectrometry. The mass spectrometric fragmentation of the nitro derivative shows prominent ions arising from the loss of the nitro group, ring enlargement of the thiazoles, and the phenylthiirene ion resulting from 1,2-cleavage of the thiazole ring. In the 4-(4-aminophenyl)-2-substituted amino derivative prominent ions result from the preferential 1,2-cleavage of the thiazole ring to give the common 2-(4-aminophenyl) thiirene ion and subsequent fragmentation of this ion.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200110402
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  • 5
    Electronic Resource
    Electronic Resource
    Conformations of side chains of somatostatin very high field proton NMR studies (1982)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 19 (1982), S. 211-215 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The high field proton NMR spectra (500 and 600 MHz) of the peptide hormone somatostatin in D2O are reported. The results obtained are used to derive values of the couplings and chemical shifts related to the solution conformation of several of the side chains. This work resolves a discrepancy in the literature concerning the assignments of resonances in the spectrum. It also provides a means of testing the accuracy of obtaining values for these couplings and shifts in previous 2D NMR studies at lower field from strongly coupled multiplets in spectra of this complexity.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270190410
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  • 6
    Electronic Resource
    Electronic Resource
    Site of protonation and bifunctional group interactions in α,ω-hydroxyalkylamines (1981)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 16 (1981), S. 176-179 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chemical ionization mass spectrometry and mass analyzed ion kinetic energy spectrometry in conjunction with collision induced dissociation are used to study the fragmentation behavior of a series of α,ω-hydroxyalkylamines. The difference between the ionic population present at equilibrium in the source, and that which is sampled under nonequilibrium conditions, is revealed in the striking differences observed in product distributions in the chemical ionization mass spectra and the mass analyzed ion kinetic energy spectra. The major fragmentations in the mass analyzed ion kinetic energy spectra, loss of NH3 and H2O, show large variations in intensity as a function of the chain length between the hydroxy and amino functionalities. These results are rationalized through analysis of the relevant thermochemical data.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210160407
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  • 7
    Electronic Resource
    Electronic Resource
    Fast atom bombardment mass spectrometry of non-volatile organometallic compounds. Rhodium, iridium and platinum complexes containing a cumulene ligand (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 19 (1984), S. 107-112 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Fast atom bombardment (FAB) mass spectrometry has been used to examine a series of rhodium, iridium and platinum organimetallic complexes, in which a cumulene ligand is attached to the metal in either σ-or π-bonding fashion. The most intense ion formed in the rhodium and platinum series is the metal-bis(triphenylphosphine) ion, while the [Ir(P(C6H5)3)2CO]+ ion is most intense for the iridium series. The platinum complexes show the most intense molecular ion peaks (up to 35% relative intensity), while the rhodium complexes show the least intense molecular ion peaks. The primary fragmentations of all these complexes occur at the metal-ligand bonds. The cumulenic ligand is lost as an impact unit in all cases. The FAB mass spectra of Rh(P(C6H5)3)3Cl (Wilkinson's catalyst), Ir(P(C6H5)3)2COCl (Vaska's compound), Rh(P(C6H5)3)2COCl and Pt(P(C6H5)3)2(C2H4)-synthetic precursors or related compounds to the organometallic complexes examined here-are included for comparison.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210190302
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  • 8
    Electronic Resource
    Electronic Resource
    Thermospray high performance liquid chromatography/mass spectrometric identification of a bladder carcinogen metabolite isolated from guinea pig urine (1990)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 19 (1990), S. 601-608 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An in vivo uninary metabolite of the bladder carcinogen 2-amino-4-(5-nitro-2-furyl) thiazole was isolated from guinea pig urine and was identified by direct analysis using thermospray mass spectrometry/high-performance liquid chromatography as 1-(2-amino-4-(5-nitro-2-furyl)-2-thiazolyl)-1-deoxy-β-D-glucopyranuronic acid. The structure of this metabolite was also established by chemical synthesis. Both positive and negative ion thermospray mass spectrometry of the conjugate showed fragment ions resulting from cleavage across the pyran ring of the glucuronic acid comprising of aglycone moiety. These characteristic fragment ions may be diagnostic for identification of N-glucuronides from O-glucuronides.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200191005
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  • 9
    Electronic Resource
    Electronic Resource
    Quantification of plasma phenylethylamine by combined gas chromatography/electron capture negative ion mass spectrometry of the N-acetyl-N-pentafluorobenzoyl derivative (1991)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 20 (1991), S. 375-381 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An ultrasensitive method capable of detection and quantification of β-phenylethylamine in 1 ml of human plasma has been developed using gas chromatography/electron capture negative ion mass spectrometry. Phenylethylamine and tetra-deutero phenylethylamine internal standard in plasma were acetylated, extracted into organic solvent and then further acylated with pentafluorobenzoyl chloride. The N-acetyl-N-pentafluorobenzoyl-phenylethylamines were detected by high-resolution single ion monitoring of the molecular ions. Normal plasma levels were found to be 41.5 ± 10.7 pg ml-1, in accordance with results of a previous high-performance liquid chromatographic method.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200200608
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  • 10
    Electronic Resource
    Electronic Resource
    Structural characterization by mass spectrometry of native and recombinant human relaxin (1990)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 19 (1990), S. 655-664 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mass spectrometry has played a key role in characterizing the primary structure of native and recombinant relaxin, a peptide hormone that induces ripening of the cervix prior to childbirth. The peptide is composed of two chains, A and B, and is formed from a single-chain prohormone, as is insulin. Aside from conserved cysteines, though, it has little sequence homology with insulin. Due to the small amounts of native peptide initially available ( 〈 10 pmol), traditional techniques could not provide information on the blocked A-chain sequence, on the carboxy-terminal sequences, nor on other possible post-translational modifications. Mass measurements by fast atom bombardment (FAB) were made on reduced human relaxin isolated from corpora lutea. The detection limit by FAB for reduced relaxin was 500 fmol. The B-chain was four amino acids shorter than expected from comparison of the previously known cDNA sequence with homologous rat and porcine sequences. The A-chain, as predicted, was 24 amino acids in length and had a pyroglutamic acid residue on the amino-terminus. The purified samples were homogeneous with no other post-translational modifications. The recombinant relaxin molecule was also extensively characterized by mass spectrometry. In addition to the intact molecule, all tryptic peptides were characterized by FAB. A capillary high-performance liquid chromatography continuous-flow FAB system, developed for high-sensitivity peptide mapping, aided in these analyses. Finally, the three disulfide bonds were shown by tandem mass spectrometry to match those of insulin.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200191105
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