Publication Date:
1989-12-08
Description:
A vaccine against human immunodeficiency virus (HIV) would be highly effective in stopping the acquired immunodeficiency syndrome (AIDS) epidemic. A comprehensive evaluation of potential vaccine methodologies can be made by means of the simian model for AIDS, which takes advantage of the similarities in viral composition and disease potential between simian immunodeficiency virus (SIV) infection of rhesus macaques and HIV infection in humans. Immunization with a formalin-inactivated whole SIV vaccine potentiated with either alum and the Syntex adjuvant threonyl muramyl dipeptide (MDP) or MDP alone resulted in the protection of eight of nine rhesus monkeys challenged with ten animal-infectious doses of pathogenic virus. These results demonstrate that a whole virus vaccine is highly effective in inducing immune responses that can protect against lentivirus infection and AIDS-like disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphey-Corb, M -- Martin, L N -- Davison-Fairburn, B -- Montelaro, R C -- Miller, M -- West, M -- Ohkawa, S -- Baskin, G B -- Zhang, J Y -- Putney, S D -- New York, N.Y. -- Science. 1989 Dec 8;246(4935):1293-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Delta Regional Primate Research Center, Tulane University, Covington, LA 70434.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2555923" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylmuramyl-Alanyl-Isoglutamine/immunology
;
Adjuvants, Immunologic/administration & dosage
;
Alum Compounds/administration & dosage
;
Animals
;
Antibodies, Viral/biosynthesis
;
Chromatography, High Pressure Liquid
;
Disease Models, Animal
;
Formaldehyde
;
Immunization, Secondary
;
Leukocyte Count
;
Lymphocytes/immunology/microbiology
;
Macaca mulatta
;
Retroviridae Infections/*prevention & control
;
Retroviridae Proteins/immunology
;
Simian Immunodeficiency Virus/*immunology/isolation & purification
;
Vaccines, Inactivated/administration & dosage/immunology
;
Viral Vaccines/administration & dosage/*immunology
;
Virion/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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