ISSN:
0935-6304
Keywords:
Microcolumn liquid chromatography
;
Solvent modulation
;
Mobile-phase gradient programming
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
An innovative solvent delivery method termed solvent modulation has been developed to control solute retention in liquid chromatography. Solvent modulation is the technique whereby individual solvent zones are introduced onto the chromatographic column in a known random orrepeating sequence. Because the solvent zones are of constant composition and are spatially separated from one another, solute retention is controlled independently in each zone. Hence, the overall retention of a solute is a time-weighted average of the capacity factors in the solvent zones it has encountered. Solvent modulation offers a simple, versatile, and accurately modeled means to control and predict solute retention in liquid chromatography.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240111203
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