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The Influence of Liposomal Encapsulation on Sodium Cromoglycate Pharmacokinetics in Man (1989)

Taylor, Kevin M. G. ; Taylor, Glyn ; Kellaway, Ian W. ; [et al.]

Springer

Pharmaceutical research 6 (1989), S. 633-636

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ISSN: 1573-904X

Keywords: sodium cromoglycate ; liposome ; liposomal ; drug delivery system ; pulmonary drug delivery

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract The pharmacokinetics of pulmonary-administered sodium cromoglycate (SCG) has been studied in five healthy volunteers. SCG, 20 mg, was inhaled as a solution and encapsulated in dipalmitoyl phosphatidylcholine/cholesterol (1:1) liposomes. Liposomal SCG produced detectable drug levels in plasma from four volunteers taken 24 and 25 hr after inhalation. Inhaled SCG solution, although producing peak plasma levels more than sevenfold greater than liposomal drug, was not detectable in 24-hr samples from any volunteer. The decline in plasma levels following inhalation of liposomal SCG (reflecting the absorption phase) was best described by a biexponential equation. The two absorption rate constants differed by more than an order of magnitude. The rapid absorption phase was probably due to free or surface-adsorbed SCG in the liposomal formulation, since the absorption rate constant for this phase did not differ significantly from the absorption rate constant for SCG in solution. The phase of slow drug absorption may then be attributed to absorption of drug released from vesicles. The data indicate that encapsulation of SCG prior to pulmonary administration prolonged drug retention within the lungs and altered its pharmacokinetics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1015917918130

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Crystallization studies of poly(ε-caprolactone).I. Morphology and kinetics (1987)

Phillips, Paul J. ; Rensch, Gregory J. ; Taylor, Kevin D.

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part B: Polymer Physics 25 (1987), S. 1725-1740

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ISSN: 0887-6266

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: The crystallization behavior of three molecular weight samples of poly(ε-caprolactone) has been studied as a function of temperature. Crystallization begins in the form of axialities and changes to spherulite growth as time progresses, presumably owing to the molecular weight distribution. Determinations of equilibrium melting point and analyses of growth kinetics are complicated by a major lamellar thickening process occurring at the crystallization temperature. Secondary nucleation analyses of spherulitic growth rates, carried out assuming a similar growth face to that of polyethylene, result in values of σσe. Use of the Thomas-Stavely relation to calculate a value of σ results in values of fold-surface free energy, σe, similar to that of polyethylene.

Additional Material: 14 Ill.