Publication Date:
1986-04-04
Description:
An experimental approach, which in this study was applied to the malarial system, can be used to analyze the molecular structure and organization of individual phospholipids in a wide variety of biological membranes. Electron spin resonance spectroscopy was used to investigate the structural modifications of the major red cell phospholipids that occur in erythrocyte membranes infected with the human malarial parasite, Plasmodium falciparum. These modifications were correlated with the intracellular developmental stage of the parasite. Phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were increasingly disordered (fluidized) as infection progressed. This disordering occurred at different rates and to varying extents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taraschi, T F -- Parashar, A -- Hooks, M -- Rubin, H -- 2SO7RR05413/RR/NCRR NIH HHS/ -- SO7RR05415-22/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):102-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3006251" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Electron Spin Resonance Spectroscopy
;
Erythrocyte Membrane/parasitology/*ultrastructure
;
Humans
;
Malaria/blood
;
Membrane Lipids/blood
;
Phospholipids/blood
;
Plasmodium falciparum/*growth & development
;
Spin Labels
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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