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  • 1
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    Antiprotozoal activity of tricyclic compounds (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-11-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hewlett, E L -- Pearson, R D -- Zilberstein, D -- Dwyer, D M -- New York, N.Y. -- Science. 1985 Nov 29;230(4729):1063-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4059923" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents, Tricyclic/*therapeutic use ; Clomipramine/therapeutic use ; Leishmaniasis/*drug therapy ; Membranes/drug effects ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Vaccination againstBoophilus microplus: Localization of antigens on tick gut cells and their interaction with the host immune system (1989)
    Springer
    Experimental and applied acarology 7 (1989), S. 43-58 
    Details
    ISSN: 1572-9702
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cattle have been vaccinated againstBoophilus microplus with antigens derived from partially fed female ticks. The immune response of the host lyses the gut cells of adult ticks, causing a reduction in the number, weight and reproductive capacity of engorging ticks. This response is different from the immunity that cattle acquire after repeated tick infestation. Evidence is presented that the antigens used in vaccination are located on the plasma membrane of the gut cells and it is unlikely that these antigens are secreted into the host during feeding. Vaccination using such ‘concealed’ antigens may not encounter the mechanisms of immune evasion that parasites usually demonstrate. In-vitro assays suggest that vaccination immunity is not dependent on the need to stimulate cell-mediated responses. Immunoglobulin G alone, or with the aid of complement, is enough to damage tick gut. The normal function of the one protein antigen isolated so far is unknown but we speculate that it serves some vital function on the cell plasma membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01200452
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    Paper (German National Licenses)
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