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  • 1
    Electronic Resource
    Electronic Resource
    Structure and dynamics of a fluorescent DNA oligomer containing the EcoRI recognition sequence: fluorescence, molecular dynamics, and NMR studies (1989)
    s.l. : American Chemical Society
    Biochemistry 28 (1989), S. 9095-9103 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00449a021
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  • 2
    Electronic Resource
    Electronic Resource
    Distribution of acetylator phenotype in relation to age and sex in Swedish patients (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 311-315 
    Details
    ISSN: 1432-1041
    Keywords: acetylator phenotype ; isoniazid ; age distribution ; sex distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 310 Swedish patients, the distribution of acetylator phenotype was studied by determination of the half-life of isoniazid (INH T1/2). The expected bimodal distribution was found in the complete study group, but was not always clearly apparent after subgrouping for age and sex. Mean INH T1/2 was higher in males and tended to increase with age. The difference in INH T1/2 between males and females was small in younger individuals (below 46 years of age) and showed a gradual increase with age. In older individuals (above 65 y) mean INH T1/2 was 42 min longer in males than in females. In the females, mean INH T1/2 was relatively constant in all age groups. The effect of age on acetylator phenotype, previously reported by other workers, appears to have been confirmed but only in males. It may be influenced by concurrent treatment for certain diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543329
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular dynamics simulations of ribonuclease T1 (1988)
    Springer
    European biophysics journal 16 (1988), S. 287-297 
    Details
    ISSN: 1432-1017
    Keywords: Ribonuclease T1 ; protein dynamics ; molecular dynamics ; protein-nucleic acid interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Molecular dynamics simulations in vacuum and with a water sphere around the active site were performed on the 2′GMP-RNase T1 complex. The presence of water led to the maintenance of the 2′-GMP-RNase T1 interactions as compared to the X-ray structure, including the hydrogen bonds implicated in the enzyme-inhibitor recognition process. The sidechain of His92 in the molecular dynamics water simulation, however, hydrogen bonds directly to the phosphate of 2′GMP in contrast to the X-ray structure but in support of the role of that residue in the enzyme's catalytic mechanism. Fluctuations of activesite residues are not strongly influenced by water, possibly owing to the exclusion of water by the bound 2′GMP, which did show an increase in mobility. Analysis of the 2′GMP-RNase T1 interactions versus time reveal an equilibrium fluctuation in the presence of water, leading to a less favorable 2′GMP-RNase T1 interaction energy, suggesting a possible relationship between picosecond fluctuations and inhibitor dissociation occurring in the millisecond time domain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254065
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  • 4
    Electronic Resource
    Electronic Resource
    The interaction of erythromycin with theophylline (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 493-498 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; erythromycin ; drug interaction ; aminophylline ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the interaction of erythromycin with theophylline. We gave ten healthy volunteers theophylline as an intravenous loading dose (5 mg·kg−1) over 1 h, followed by a maintenance infusion (0.5 mg·kg−1·h−1) for 5 h. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of theophylline were determined during the infusion periods. The concentrations of erythromycin were measured for 8 h, after one week of treatment, and also after the last erythromycin dose, simultaneously with the second theophylline infusion. Concentrations within the therapeutic range were obtained with both drugs. A significant increase in both AUC and mean plasma concentrations of theophylline was seen during erythromycin treatment. The plasma clearance of theophylline was reduced in 9 of the 10 subjects. Renal clearance increased correspondingly, but the change was not statistically significant. Serum concentrations of erythromycin fell significantly, by more than 30%, with concurrent theophylline medication. We conclude that an interaction between theophylline and erythromycin, affecting both drugs, can be shown with concentrations of the drugs within the therapeutic range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637676
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of nimodipine in patients with aneurysmal subarachnoid haemorrhage (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 421-425 
    Details
    ISSN: 1432-1041
    Keywords: nimodipine ; subarachnoid haemorrhage ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Patients with a ruptured supratentorial aneurysm undergoing early surgery after the subarachnoid haemorrhage were treated postoperatively with nimodipine to prevent delayed ischaemic dysfunction. It was given first as a continuous intravenous infusion 2 mg/h (mean dose 0.5 µg/kg/min) for at least 7 days, and then orally (45 mg × 6) for at least a further 7 days. During the i.v. infusion, the mean plasma concentration was 26.6±1.8 ng/ml. The plasma clearance ranged from 0.57 to 1.77 l/kg/h and was negatively correlated with the age of the patient. Immediately prior to successive oral doses, the mean plasma concentration was 13.2 ng/ml (range〈3–38.8 ng/ml). The peak level was usually found after 1 h; it ranged from 7.0–96.0 ng/ml. Mean bioavailability was 15.9%. The nitropyridine metabolite was found in measurable concentrations only after oral treatment with nimodipine. In some cases, the concentration of metabolite exceeded that of the parent compound. The three patients investigated who developed delayed ischaemic dysfunction had plasma concentrations well within the range in patients who did not, so it seems unlikely that the therapeutic failure could be attributed to individual deviations in the pharmacokinetics of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607954
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  • 6
    Electronic Resource
    Electronic Resource
    Patients’Experience of Transvaginal Follicle Aspiration under Local Anesthesia (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 541 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb22249.x
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  • 7
    Electronic Resource
    Electronic Resource
    The evolution of flowers with deep corolla tubes (1988)
    [s.l.] : Nature Publishing Group
    Nature 334 (1988), S. 147-149 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Floral design ranges from open dish-shaped to stereomorphic with tubes exceeding 30 cm. In "On the Origin of Species', p. 95, Darwin2 reported that certain length relations between the cor-rolla of red clover and the tongue of bees were crucial for successful mutualism and that by the survival of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/334147a0
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  • 8
    Electronic Resource
    Electronic Resource
    Measurement of ammonium utilization byEscherichia coli under ammonium limitation by means of an ammonia-sensitive semiconductor device (1988)
    Springer
    Applied microbiology and biotechnology 29 (1988), S. 269-274 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The concentration of ammonium in the medium of anEscherichia coli fermentation during ammonium limitation was followed by means of a newly developed semiconductor device, the ammonia gas-sensitive thin platinum metal oxide semiconductor structure (Pt-TMOS). It has been shown that the ammonia sensitivity of the sensor was sufficient for determination of ammonium concentrations at growth limitation due to ammonium depletion. Furthermore, the corresponding ATP concentration and dissolved oxygen tension during the progress of the fermentation was followed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00939320
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  • 9
    Electronic Resource
    Electronic Resource
    Measurement of ammonium utilization byEscherichia coli under ammonium limitation by means of an ammonia-sensitive semiconductor device (1988)
    Springer
    Applied microbiology and biotechnology 29 (1988), S. 269-274 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The concentration of ammonium in the medium of anEscherichia coli fermentation during ammonium limitation was followed by means of a newly developed semiconductor device, the ammonia gas-sensitive thin platinum metal oxide semiconductor structure (Pt-TMOS). It has been shown that the ammonia sensitivity of the sensor was sufficient for determination of ammonium concentrations at growth limitation due to ammonium depletion. Furthermore, the corresponding ATP concentration and dissolved oxygen tension during the progress of the fermentation was followed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01982915
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  • 10
    Electronic Resource
    Electronic Resource
    Pollination ofPlectranthus vestitus (Lamiaceae) by trap-lining hovering bees in Madagascar (1985)
    Springer
    Plant systematics and evolution 150 (1985), S. 223-236 
    Details
    ISSN: 1615-6110
    Keywords: Angiosperms ; Lamiaceae ; Plectranthus ; P. vestitus ; Pollination ; melittophily ; hovering bees ; Flora of madagascar
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In a primary forest on the Central Plateau of MadagascarPlectranthus vestitus (Lamiaceae) was principally pollinated by the beePachymelus limbatus (Hymenoptera, Anthophoridae). A species ofStylogaster (Diptera, Conopidae) acted as a co-pollinator. Flower — pollinator interactions are described. The bee performed pollination while hovering, a flower-visit lasting onlyc. 0.3 seconds. Floral features such as shape and size of the corolla tube, and the lack of a landing place suggest specialization to hovering anthophorid beepollinators. Floral biology and pollination in the genusPlectranthus are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00984198
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