ISSN:
1420-9071
Keywords:
Bone cells
;
bisphosphonates
;
lactate production
;
alkaline phosphatase
;
fatty acid oxidation
;
bone resorption
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Dihalogenmethylenebisphosphonates increase alkaline phosphatase activity and fatty acid oxidation in calvaria cells in culture (Cl2MBP〉Br2MBP≊F2MBP). The monohalogen C1MBP and the non-halogenated analogues are less active on phosphatase and inactive on or inhibitory towards fatty acid oxidation. The three dihalogenbisphosphonates and C1MBP inhibit bone resorption in vivo, Cl2MBP most strongly.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01942514
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