ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The B 5/B 5 genotype, in Leghorns, was associated with a high degree of metastasis of Rous sarcoma virus-induced tumors, but in combination with a Leghorn-New Hampshire background markedly less metastasis occurred. Initially, four mating types were used: B 5/B 5 × B 5/B 5 chickens from the F5 generation of the cross of Leghorn lines 61 and 151, B 24/B 24 × B 24/B 24 chickens from line UNH 105 (New Hampshires), and reciprocal crosses of B 5/B 5 × B24/B24 chickens. Subsequently, F2 generation progeny of the cross of B5/B5 and B 24/B 24 breeders, as well as B 24/B 24 line UNH 105 and B 5/B 5 (61 × 151)F2 chickens, were used. Six-week-old chickens were inoculated in the wingweb with Rous sarcoma virus. Chickens dying during a 10-week period after inoculation were necropsied and suspect metastatic lesions examined histologically. Among 234 terminal chickens from the initial four mating types the incidence of metastasis associated with B 5/B 5 Leghorns (66%) was substantially higher than for B 24/B 24 New Hampshires (12%) and B 5/B 24 progeny of reciprocal Leghorn-New Hampshire crosses (19 and 24%). Subsequently, among 524 terminal hosts in the Leghorn-New Hampshire F2 population, B genotype significantly influenced tumor dissemination. However, among 52 concurrently challenged B 5/B 5 hosts from the (61 × 151)F2 population the incidence of metastasis (60%) was significantly higher than among 122 B 5/B 5 hosts from the Leghorn-New Hampshire F2 population (31%), indicating a non-major histocompatibility complex genetic effect on metastasis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00430915
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