Publication Date:
1988-05-20
Description:
The human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type I (HTLV-I) are two distinct human retroviruses that infect T cells. Recent epidemiologic studies have identified a cohort of individuals that are coinfected with both viruses. It is reported here that human peripheral blood leukocytes infected with HIV-1 in vitro can be induced to produce large quantities of HIV-1 after mitogenic stimulation by noninfectious HTLV-I virions. It is also shown that HTLV-I virions may exert this effect prior to, immediately following, or well after the cells are infected with HIV-1. These results provide further impetus for epidemiologic studies of dually infected individuals to determine whether HTLV-I may act as a cofactor for acquired immunodeficiency syndrome (AIDS).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zack, J A -- Cann, A J -- Lugo, J P -- Chen, I S -- CA 32737/CA/NCI NIH HHS/ -- CA 38597/CA/NCI NIH HHS/ -- CA 43370/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1988 May 20;240(4855):1026-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Hematology-Oncology, UCLA School of Medicine 90024.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2835813" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/microbiology
;
Deltaretrovirus/*immunology
;
HIV/*growth & development/isolation & purification
;
Humans
;
*Lymphocyte Activation
;
T-Lymphocytes/immunology/*microbiology
;
Virus Activation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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