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  • Springer  (79)
  • 1985-1989  (65)
  • 1935-1939  (14)
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  • 1
    ISSN: 1432-1041
    Keywords: azathioprine ; 6-thiouric acid ; 6-mercaptopurine ; renal transplantation ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The immunosuppressive activity of azathioprine (AZA) is unpredictable and depends on the formation of intracellular thiopurine ribonucleotides. However, the quantification of these active thiopurines presents difficult analytical problems. It has recently been postulated that plasma concentrations of 6-thiouric acid (6-TU) and 6-mercaptopurine (6-MP), metabolites of AZA, may provide more readily measurable indices of the pharmacologic activity of AZA. In order to evaluate the utility of 6-TU and 6-MP plasma concentrations in monitoring AZA therapy, we studied their pharmacokinetics in 6 renal transplant patients, and their in vitro immunosuppressive potency in a mixed lymphocyte proliferation assay. A peak plasma 6-TU concentration of 710.7 ng/ml was observed at 3.8 h after oral dosing. Good correlation was observed between the elimination t1/2 of 6-TU and serum creatinine, and between AUC over 24 h and serum creatinine. However, we did not observe a second peak in plasma 6-TU concentration that could be attributed to the degradation of active AZA metabolites. 6-MP plasma concentrations in the patients were low (mean peak concentration 36.0 ng/ml) and rapidly disappeared within 8 h. In vitro immunosuppressive activity could not be demonstrated for 6-TU over a concentration range of 1.25 ng/ml to 0.25 mg/ml. We conclude that 6-TU is pharmacologically inert and is primarily eliminated by the kidneys. Our findings currently do not support the use of plasma concentrations of 6-TU or 6-MP to monitor AZA therapy. In order to optimize AZA therapy, analytical techniques that are technically feasible and that can directly quantify the active intracellular thiopurines are being explored.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archiv der Mathematik 47 (1986), S. 408-409 
    ISSN: 1420-8938
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0983
    Keywords: Plant mitochondrial DNA ; Restriction enzyme analysis ; rRNA genes ; Tomato cell suspension cultures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mitochondrial DNA (mtDNA) from Lycopersicon esculentum was purified from cell suspension cultures. The DNA, isolated from mitochondria purified by two successive sucrose density gradients, was uncontaminated with nuclear DNA or DNA from proplastids. The total molecular weights of BamHI, BglI, and BglII fragments indicate a mitochondrial genome size of at least 270 kb. Cross hybridization between tomato mtDNA and cloned spinach plastid genes revealed some homology. In hybridization experiments using cloned mitochondrial rRNA genes and BamHI digested total mtDNA the presence of recombination repeats is demonstrated.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 23 (1935), S. 453-456 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 25 (1937), S. 417-420 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1939
    Keywords: Allocation patterns ; Restionaceae ; Nitrogen ; Dry mass ; Fynbos
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The annual growth pattern of male plants of the endemic, dioecious fynbos species, Thamnochortus punctatus, revealed sequential growth of the various below-and above-ground organs. Root and rhizome development were favoured in the wet winter months while culm elongation occurred in the warmer but drier spring to summer period. The reproductive phase of development followed in the hot dry summer and autumn. The asynchronous pattern of growth is suggested to enable the plant to maximize utilization of scarce resources within the confines of the environmental controls determined by the mediterranean-climate. Maximum root and rhizome activity in the rainy season enabled the plant to absorb and store nitrogen in mature culms for later above ground organ development. As the absorption of nitrogen from senscing material is essential for this pattern of organ development to assist in alleviating nutrient scarcity the high degree of nitrogen reabsorption, 35 to 70% for branches and culms respectively, shows the potential importance of asynchronous organ growth in overcoming nitrogen limitation of plant growth. Comparisons of dry mass and nitrogen allocation patterns indicate that developmental strategies employed by evergreen, perennial plants in climatically and edaphically constrained environments cannot be deduced from biomass allocation patterns alone as they do not appear to reflect strategies evolved to overcome nutrient limitation.
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  • 7
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Oecologia 81 (1989), S. 412-417 
    ISSN: 1432-1939
    Keywords: Myrmecochory ; Fynbos ; Regeneration ; Fire ; Nutrient
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Leucospermum conocarpodendron (L.) Buek (Proteaceae) seedlings were excavated several months after a fire in Cape fynbos. Seedlings under burnt parental skeletons had short hypocotyls (mean 25 mm) indicating passive dispersal whereas seedlings in the open were more deeply buried (mean 48 mm) by ants. Soil nutrient concentrations at the site of germination were negatively related to depth of burial and distance from parent. Ant dispersal resulted in seedlings emerging in soils with lower nutrient concentrations than passively dispersed seeds. Tissue analysis supported the soil results with lower P content in seedlings from open (ant dispersed) sites. Seedling survival in the first year of establishment was also lower in open sites, but not significantly so. However seedlings were slightly taller in the open. The results of this study, the first on naturally occurring intraspecific variation in myrmecochory, strongly contradict current explanations for the high incidence of myrmecochory in nutrient poor environments.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 38 (1988), S. 1-1 
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1435-8107
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Chenopodium rubrum plants, induced to flower by three cycles of 12 h darkness and 12 h light, produced 42% less ethylene than vegetative plants kept under continuous light. Plants that had each dark cycle broken by 2 h light in the middle did not flower and produced almost as much ethylene as the vegetative plants. Shoots and roots of plants of all three experimental treatments had a similar content of 1-aminocyclopropane-1-carboxylic acid (ACC), the mean amounting to about 2 nmol · g−1 dry weight. Also the content of N-malonyl-ACC (MACC) was similar in shoots of all three treatments. MACC content in roots was shown to be much higher, especially in the treatments with three dark periods (about 85 nmol · g−1 dry weight). When labeled [2,3-14C] ACC was administered, the relative contents of ACC and MACC were very similar among all three treatments. The only process influenced by flower induction was ACC conversion to ethylene. Induced plants converted 36% less ACC than the vegetative ones. Plants subjected to night-break converted almost as much ACC to ethylene as vegetative plants. It is concluded that flower induction in the short-day plantChenopodium rubrum decreases ethylene production by decreasing their capability of converting ACC to ethylene.
    Type of Medium: Electronic Resource
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